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COMMISSION ON NARCOTIC DRUGS, 7TH SESSION, SUMMARY RECORD OF THE 162ND MEETING, HELD AT HEADQUARTERS, NEW YORK, ON FRIDAY, 18 APRIL 1952
It 1-ms thus possible to foresee the dangers of keto-bemiclone if it were taken into account that it had been rut on the market extremaly recently. (...) ANSLINGER (United States of America) stated that the use of keto- bemidone was not prohibited by law in the Un:Ited States. (...) VAILLE (France) stated th'lt the manufacture and use of' keto-bemidom -were prohibitec; in r cil1:;e. He -wished ·so 1-,:::Dw whether the therapeutic value of' keto-bemido~o vlL.S eq1..
Language:English
Score: 1751104.5 - https://daccess-ods.un.org/acc...t?open&DS=E/CN.7/SR.162&Lang=E
Data Source: ods
Metabolites identified in hydrolysed organo-extractable fraction containing 96.8% of the milk radioactivity. 3- keto-carbofuran (1.2% of the TRR) was also identified. carbosulfan212 2Comprising 5-hydroxy-carbofuran (1.1%), 3-keto-carbofuran (1.5%), N-hydroxy-carbofuran (0.5%), carbofuran (0.2%), carbosulfan (0.1%) and a combination of 3-keto-carbosulfan sulfone, 3-hydroxy-carbosulfan and carbosulfan sulfone (1%, unresolved by the HPLC system). 3Comprising 5-hydroxycarbofuran (1.7%), 3-keto-carbofuran (3.7%), N-hydroxy-carbofuran (1%), carbofuran (0.8%), carbosulfan (0.1%) and a combination of 3-keto-carbosulfan sulfone, 3-hydroxy-carbosulfan and carbosulfan sulfone (0.3%, not resolved by the HPLC system). (...) After 8 days the identified residues were carbofuran, 3-hydroxycarbofuran, carbosulfan sulfone, the 7-phenol, 3-keto-7-phenol, N-hydroxymethyl-carbofuran, 3-keto-carbofuran and 3-keto-carbosulfan sulfone. (...) It is capable of measuring residues of carbosulfan, its carbamate metabolites carbofuran, 3-keto- carbofuran and 3-hydroxycarbofuran, the 7-phenol, 3-keto-7-phenol, and 3-hydroxy-7-phenol metabolites, and dibutylamine.
Language:English
Score: 1720769.3 - https://www.fao.org/fileadmin/...JMPR/Evaluation97/Carbosul.PDF
Data Source: un
The metabolic pathway includes oxidation to 3-hydroxy- and 3-keto-carbofuran and hydroxylation to phenolic metabolites. (...) Compound Forage Silage % of TRR mg/kg as carbofuran % of TRR mg/kg as carbofuran carbofuran 14 0.11 0.18 <0.001 carbofuran aglycone 2.4 0.019 2.1 0.003 3-keto-carbofuran 1.6 0.013 - - 3-keto-carbofuran aglycone 0.28 0.003 0.91 0.001 3-hydroxy-carbofuran 13 0.11 1.3 0.002 3-hydroxy-carbofuran aglycone 9.7 0.078 7.9 0.011 7-phenol 0.47 0.004 0.088 <0.001 carbofuran100 Compound Forage Silage % of TRR mg/kg as carbofuran % of TRR mg/kg as carbofuran 7-phenol aglycone 7.5 0.060 2.8 <0.001 3-keto-7-phenol 4.8 0.039 1.4 0.002 3-keto-7-phenol aglycone 5.6 0.045 2.4 0.003 3-hydroxy-7-phenol 2.4 0.020 0.88 0.001 3-hydroxy-7-phenol aglycone 3.6 0.029 2.3 0.003 Total 65 0.53 22 0.026 The major components of the radiolabelled residue identified in the forage were carbofuran and 3-hydroxy-carbofuran, free and conjugated and in the silage 3-hydroxy-carbofuran, free and conjugated. (...) The structure of 3-keto-carbofuran was confirmed by mass spectrometry and the structure of carbofuran was confirmed by two-dimensional TLC.
Language:English
Score: 1658819.5 - https://www.fao.org/fileadmin/...JMPR/Evaluation97/Carbofur.PDF
Data Source: un
Residues of spirotetramat (STM), STM cis-enol, STM cis-keto-hydroxy, BYI08330 monohydroxy, STM enol- glucoside were determined separately and each expressed as the parent compound. (...) Rate b (kg ai/ha) DAT (days) STM STM cis- enol STM cis- keto- hydroxy STM enol- glucoside STM mono- hydroxy Sum of STM and cis- enol Total residue of STM+4 Cont. (...) Calc 1: Residues of STM, STM cis-enol, STM cis-keto-hydroxy, BYI08330 monohydroxy, STM enol-glucoside each expressed as STM.
Language:English
Score: 1628548.6 - https://www.fao.org/fileadmin/...on2015/SPIROTETRAMAT__234_.pdf
Data Source: un
Shtetet riperterine angazhimin e tyre per respektimin e normave themelore te punes te njohura ne nivel nderkombetar, rikujtuan se ILO eshte organi kompetent per t’i vendosur keto norma dhe per te siguruar zbatimin e tyre dhe riafirmuan mbeshtetjen e tyre ndaj aktiviteteve te saj per promovimin e ketyre normave. (...) Njeh detyrimin qe i bie Organizates te ndihmoje Anetaret e saj, ne pergjigje te nevojave te dala dhe te shprehura te tyre, ne menyre qe te arrihen keto objektiva duke perdorur plotesisht mjetet e saj kushtetuese, praktike dhe buxhetore, perfshire ketu mobilizimin e burimeve te huaja dhe mbeshtetjes se huaj, si dhe duke inkurajuar organizata te tjera nderkombetare me te cilat ILO ka vendosur marredhenie, ne baze te nenit 12 te Kushtetutes se saj, t’i mbeshtesin keto perpjekje: a) duke ofruar nje bashkepunim teknik dhe sherbime keshillimi te destinuara te nxisin ratifikimin dhe zbatimin e konventave themelore; b) duke ndihmuar ata Anetare te saj qe nuk jane ende ne gjendje te ratifikojne gjithe apo disa nga keto konventa ne perpjekjet e tyra per te respektuar, nxitur dhe realizuar parimet lidhur me te drejtat themelore qe jane objekt i ketyre konventave; c) duke ndihmuar Anetaret e saj ne perpjekjet e tyre per te vendosur nje klime te favorshme per zhvillimin ekonomik dhe social. 4. (...) Formularet e ketyre raporteve do te konceptohen ne menyre te tille qe nga qeverite qe nuk kane ratifikuar nje apo disa konventa themelore, te perftohen informacione mbi te gjitha modifikimet qe mund te jene bere ne legjislacionin dhe praktiken e tyre, duke mbajtur parasysh si duhet nenin 23 te Kushtetutes dhe praktiken e vendosur. 2. Keto raporte, sikurse do te mblidhen nga Zyra, do te shqyrtohen nga Keshilli Drejtues. 3.
Language:English
Score: 1564338.3 - https://www.ilo.org/wcmsp5/gro...tiveinstrument/wcms_716610.pdf
Data Source: un
Application PHI (d) Residue (mg/kg) expressed as spirotetramat equivalents a kg ai/ha n Int. days Total/ season, kg ai /ha spiro enol keto -OH mono- OH enol -Glc total spiro spir o + enol GAP, Canada 0.20 7 0.44 7 Sainte- Anne-de- Kent, NB, Canada 2009 0.17 –0.18 3 5–8 0.52 8 0.33 0.30 0.31 (mean ) 0.37 0.37 0.37 0.39 0.37 0.38 0.11 0.11 0.11 0.035 0.033 0.034 1.2 1.2 1.2 0.68 Spirotetramat 1391 Location Year (Variety) Trial No. (...) Application PHI (d) Matrix Residue (mg/kg) expressed as spirotetramat equivalents kg ai/ha Int. days Total/ season, kg ai /ha spiro enol keto -OH mono- OH enol -Glc total spiro spiro + enol 0.43 0.097 0.086 < 0.01 < 0.01 0.63 0.53 a Mean value of residues was expressed as a bold letter. (...) Application PHI (d) Residue (mg/kg) expressed as spirotetramat equivalents a kg ai/ha n Int. days Total/ season, kg ai /ha spiro enol keto -OH mono- OH enol -Glc total spiro spiro + enol GAP, USA 0.22 7 0.45 3 Fellsmere, FL 2008 (B&W 1) 0.22 2 8 0.44 3 < 0.01 < 0.01 0.13 0.14 0.077 0.083 < 0.01 < 0.01 < 0.01 < 0.01 Spirotetramat 1400 Location Year (Variety) Trial No.
Language:English
Score: 1491461.7 - https://www.fao.org/fileadmin/...Evaluation13/Spirotetramat.pdf
Data Source: un
JM93EVAL.PDF 59 CARBOFURAN (096) EXPLANATION A 2 mg/kg limit for the sum of carbosulfan, carbofuran, 3-hydroxy-carbofuran and 3-keto- carbofuran in citrus fruits was estimated by the 1984 JMPR. (...) The estimate for the sum of carbofuran and 3-hydroxy-carbofuran was intended to accommodate residues resulting from the use of carbosulfan. Keto-carbofuran was deleted from the definition.
Language:English
Score: 1420902.5 - https://www.fao.org/fileadmin/.../JMPR/Evaluation93/carbofu.pdf
Data Source: un
Case No. 2016-936 Keto (Applicant) v. Secretary-General of the United Nations (Respondent) ORDER No. 265 (2016) 1. (...) UNDT/2016/064, in the case of Keto v. Secretary-General of the United Nations, in which it dismissed Mr. Keto’s application as not receivable. 2. On 15 June 2016, Mr.
Language:English
Score: 1399162.1 - www.un.org/en/internalj...orders/order-unat-2016-265.pdf
Data Source: oaj
INCLUSION OF CARBOSULFAN IN ANNEX III TO THE ROTTERDAM CONVENTION
Both carbofuran-7-phenol and carbofuran can undergo oxidation to generate 3-hydroxy-carbofuran and 3-keto-carbofuran, which are conjugated and eliminated via urine. (...) It is noted that the assessment does not yet consider the revised residue definition for risk assessment (including free and conjugated residues of 3-keto carbofuran), and the establishment of appropriate conversion factors to take into account for residues of 3-keto carbofuran is still pending. (...) When triennial applications were simulated, 3-keto-carbofuran exceeded this trigger only in one case (FOCUS PEARL, Piacenza scenario) of the simulations.
Language:English
Score: 1365770.6 - https://daccess-ods.un.org/acc...P/FAO/RC/COP.10/7/ADD.1&Lang=E
Data Source: ods
INCLUSION OF CARBOSULFAN IN ANNEX III TO THE ROTTERDAM CONVENTION: ADDENDUM: DRAFT DECISION GUIDANCE DOCUMENT
Both carbofuran-7-phenol and carbofuran can undergo oxidation to generate 3-hydroxy-carbofuran and 3-keto-carbofuran, which are conjugated and eliminated via urine. (...) It is noted that the assessment does not yet consider the revised residue definition for risk assessment (including free and conjugated residues of 3-keto carbofuran), and the establishment of appropriate conversion factors to take into account for residues of 3-keto carbofuran is still pending. (...) When triennial applications were simulated, 3-keto-carbofuran exceeded this trigger only in one case (FOCUS PEARL, Piacenza scenario) of the simulations.
Language:English
Score: 1365770.6 - https://daccess-ods.un.org/acc...P/FAO/RC/COP.8/15/ADD.1&Lang=E
Data Source: ods