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GLOBALLY HARMONIZED SYSTEM OF CLASSIFICATION AND LABELLING OF CHEMICALS (GHS). CHAPTERS 3.1-3.4
Category 1, the highest toxicity category, has cut-off values of 5 mg/kg bodyweight by the oral route, 50 mg/kg bodyweight by the dermal route, 100 ppm for gases or gaseous vapours, 0.5 mg/l for vapours, and 0.05 mg/l for dusts and mists. (...) For example, if a mixture with an LD50 of 1000 mg/kg bodyweight were diluted with an equal volume of water, the LD50 of the diluted mixture would be 2000 mg/kg bodyweight. (...) Yes Category 2 Danger Classification not possible According to the criteria in paragraphs 2-14, does it have an: • Oral LD50 ≤ 5 mg/kg bodyweight, or • Dermal LD50 ≤ 50 mg/kg bodyweight, or • Inhalation (gas) LC50 ≤ 100 ppm, or • Inhalation (vapour) LC50 ≤ 0.5 mg/l, or • Inhalation (dust and mist) LC50 ≤ 0.05 mg/l?
Language:English
Score: 1574547.95 - daccess-ods.un.org/acce...ST/SG/AC.10/C.4/2001/22&Lang=E
Data Source: ods
DICOFOL : NOTE / BY THE SECRETARIAT
Reproductive Toxicity: Rat (diet, 2-generation study): Parental NOAEL = 0.4 mg/kg bw/day (decrease in bodyweight and bodyweight gain, changes in liver weight and hepatocytes hypertrophy). (...) Rat (diet, developmental study): Parental NOAEL = 2.5 mg/kg bw/day (decreased bodyweight and hepatocytes hypertrophy). Offspring NOAEL = 25 mg/kg bw/day (no effects). Form for notification of finai regulatory action to ban or severely restrict a chemical Page 10 Rabbit (diet, developmental toxicity): Parental NOAEL: 0.4 mg/kg bw/day (decreased bodyweight and histopathological findings). Offspring NOAEL: 4 mg/kg bw/day (reduction in neonatal bodyweight).
Language:English
Score: 1560225.6 - daccess-ods.un.org/acce...&DS=UNEP/FAO/RC/CRC.8/4&Lang=E
Data Source: ods
REVIEW OF THE DECISION LOGICS
According to the criteria in 3.1.2 to 3.1.3.4, does it have an: (a) Oral LD50 mg/kg bodyweight; or (b) Dermal LD50 50 mg/kg bodyweight; or (c) Inhalation (gas) LC50 100 ppm; or (d) Inhalation (vapour) LC50 0.5 mg/l ; or (e) Inhalation (dust/mist) LC50 . 5 mg/l? (...) Yes No According to the criteria in 3.1.2 to 3.1.3.4, does it have an: (a) Oral LD50 >50 but mg/kg bodyweight; or (b) Dermal LD50 > 200 but mg/kg bodyweight; or (c) Inhalation (gas) LC50 >500 but ppm; or (d) Inhalation (vapour) LC50 > 2.0 but mg/l; or (e) Inhalation (dust/mist) LC50 >0.5 but mg/l? (...) Yes Category 4 Warning No Classification not possible Classification not possible ST/SG/AC.10/C.4/2020/3 16 According to the criteria in 3.1.2 to 3.1.3.4, does it have an: (a) Oral LD50 >2000 but mg/kg bodyweight; or (b) Dermal LD50 >2000 but mg/kg bodyweight; or (c) Inhalation (gas, vapour and/or dust/mist) LC50 in the equivalent range of the oral and dermal LD50 (i.e. 2000-5000 mg/kg bodyweight)?
Language:English
Score: 1547811.7 - https://daccess-ods.un.org/acc...=ST/SG/AC.10/C.4/2020/3&Lang=E
Data Source: ods
PROPOSALS FOR MODIFICATION OF THE DRAFT GHS DOCUMENT / TRANSMITTED BY THE EXPERTS FROM BELGIUM, CANADA, FINLAND, GERMANY, NETHERLANDS, NORWAY, SWEDEN AND THE UNITED SATES OF AMERICA
Yes No Classification not possible ATE from Decision Logic 2 According to the criteria in paragraphs 2-14, does it have an: · Oral LD50 5 but 50 mg/kg bodyweight, or · Dermal LD50 50 but 200 mg/kg bodyweight, or · Inhalation (gas) LC50 100 but 500 ppm, or · Inhalation (vapour) LC50 0.5 but 2.0 mg/l, or · Inhalation (dust/mist) LC50 0.05 but £ 0.5 mg/l? Yes Category 2 Danger Classification not possible According to the criteria in paragraphs 2-14, does it have an: · Oral LD50 £ 5 mg/kg bodyweight, or · Dermal LD50 £ 50 mg/kg bodyweight, or · Inhalation (gas) LC50 £ 100 ppm, or · Inhalation (vapour) LC50 £ 0.5 mg/l, or · Inhalation (dust/mist) LC50 £ 0.05 mg/l? (...) Yes Category 4 Warning According to the criteria in paragraphs 2-14, does it have an: · Oral LD50 50 but 300 mg/kg bodyweight, or · Dermal LD50 200 but 1000 mg/kg bodyweight, or · Inhalation (gas) LC50 500 but 2500 ppm, or · Inhalation (vapour) LC50 2 but 10.0 mg/l, or · Inhalation (dust/mist) LC50 0.5 but 1.0 mg/l?
Language:English
Score: 1513060.5 - daccess-ods.un.org/acce...=ST/SG/AC.10/C.4/2002/4&Lang=E
Data Source: ods
GLOBALLY HARMONIZED SYSTEM OF CLASSIFICATION AND LABELLING OF CHEMICALS (GHS) / SUBMITTED BY THE GHS EDITORIAL GROUP
Hazard statement May be corrosive to metals ST/SG/AC.10/C.4/2002/16/Add.5 page 17 A2.17 Acute toxicity (See Chapter 3.1 for details) Hazard category Criteria Hazard communication elements Symbol Signal word Danger 1 LD50 5 mg/kg bodyweight (oral) LD50 50 mg/kg bodyweight (skin/dermal) LC50 100 ppm (gas) LC50 0.5 (mg/l) (vapour) LC50 0.05 (mg/l) (dust,mist) Hazard statement Fatal if swallowed. (oral) Fatal in contact with skin (dermal) Fatal if inhaled (gas, vapour, dust, mist) Symbol Signal word Danger 2 LD50 between 5 and less than 50 mg/kg bodyweight (oral) LD50 between 50 and less than 200 mg/kg bodyweight (skin/dermal) LC50 between 100 and less than 500 ppm (gas) LC50 between 0.5 and less than2.0 (mg/l) (vapour) LC50 between 0.05 and less than 0.5 (mg/l) (dust, mist) Hazard Statement Fatal if swallowed. (oral) Fatal in contact with skin (dermal) Fatal if inhaled (gas, vapour, dust, mist) Symbol Signal word Danger 3 LD50 between 50 and less than 300 mg/kg bodyweight (oral) LD50 between 200 and less than 1000 mg/kg bodyweight (skin/dermal) LC50 between 500 and less than 2500 ppm (gas) LC50 between 2.0 and less than 10.0 (mg/l) (vapour) LC50 between 0.5 and less than 1.0 (mg/l) (dust, mist) Hazard statement Toxic if swallowed.
Language:English
Score: 1506907.6 - daccess-ods.un.org/acce...AC.10/C.4/2002/16/ADD.5&Lang=E
Data Source: ods
SUBSTANCES/MIXTURES, WHICH IN CONTACT WITH WATER, RELEASE TOXIC GASES / TRANSMITTED BY THE ORGANISATION FOR ECONOMIC CO-OPERATION AND DEVELOPMENT (OECD)
Table 1: Criteria for Substances or Mixtures which in Contact with Water Emit Toxic Gases Criteria (note 4) Category Acute Toxicity Estimate of the emitted gas (note 1, note 2) 1 =100 ppm 2 =500 ppm 3 =2500 ppm 4 =5000 ppm 5 LC50 in the equivalent range of the oral and dermal LD50 2000-5000 mg/kg/bodyweight (note 3) ST/SG/AC.10/C.4/2003/9 page 4 Annex NOTE 1: See subsection 3.1.3.3(b) for explanation of Acute Toxicity Estimate (ATE). (...) NOTE 3: In the Globally Harmonized System for the Classification and Labelling of Chemicals, Chapter 3.1, numerical values for acute inhalation toxicity in Category 5 were not included but instead specified as doses “equivalent” to the range of 2000-5000 mg/kg/bodyweight by the oral or dermal route. The following value is provided as guidance in determining the equivalent dose for gases: 5000 ppm to 12500 ppm. (...) According to the criteria in paragraphs A5-A8, in contact with water, does the substance/mixture emit a gas with an LC50 in the equivalent range of oral and dermal LD50 2000-5000 mg/kg/bodyweight ? Category 4 Warning Yes No Category 5 Warning Yes
Language:English
Score: 1489714.6 - daccess-ods.un.org/acce...=ST/SG/AC.10/C.4/2003/9&Lang=E
Data Source: ods
HEALTH HAZARDS : NOTE / BY THE SECRETARIAT
Table 1: ATE values given in table 3.1.1 for acute toxicity: Categories 3 and 4 Exposure route Category 3 Category 4 Oral (mg/kg bodyweight) 300 2000 Dermal (mg/kg bodyweight) 1000 2000 Gases (ppmV) 2500 20000 Vapours (mg/l) 10 20 Dusts and Mists (mg/l) 1.0 5 Table 2: Guidance value ranges for single-dose exposures given in table 3.8.1 for specific target organ toxicity, Category 2 Route of exposure Units Category 2 Oral (rat) mg/kg body weight 2000 ≥ C 300 Dermal (rat or rabbit) mg/kg body weight 2000 ≥ C 1000 Inhalation (rat) gas ppm 5000 ≥ C 2500 Inhalation (rat) vapour mg/1 20 ≥ C 10 Inhalation (rat) dust/mist/fume mg/l/4h 5.0 ≥ C 1.0 4.
Language:English
Score: 1475498 - daccess-ods.un.org/acce...ST/SG/AC.10/C.4/2008/12&Lang=E
Data Source: ods
GLOBALLY HARMONIZED SYSTEM OF CLASSIFICATION AND LABELLING OF CHEMICALS (GHS). ANNEXES 3 AND 4
Hazard statement May be corrosive to metals ST/SG/AC.10/C.4/2001/26 page 19 Acute toxicity (See Chapter 3.1 for details) Hazard category Criteria Hazard communication elements Signal word Danger Symbol 1 LD50 5 mg/kg bodyweight (oral) LD50 50 mg/kg bodyweight (dermal) LC50 100 ppm (gas) LC50 0.5 (mg/l) (vapour) LC50 0.05 (mg/l) (dust,mist) Hazard statement Fatal if swallowed. (oral) Fatal in contact with skin (dermal) Fatal if inhaled (gas, vapour, dust, mist) Signal word Danger Symbol 2 LD50 between 5 and less than 50 mg/kg bodyweight (oral) LD50 between 50 and less than 200 mg/kg bodyweight (dermal) LC50 between 100 and less than 500 ppm (gas) LC50 between 0.5 and less than2.0 (mg/l) (vapour) LC50 between 0.05 and less than 0.5 (mg/l) (dust, mist) Hazard Statement Fatal if swallowed. (oral) Fatal in contact with skin (dermal) Fatal if inhaled (gas, vapour, dust, mist) Signal word Danger Symbol 3 LD50 between 50 and less than 300 mg/kg bodyweight (oral) LD50 between 200 and less than 1000 mg/kg bodyweight (dermal) LC50 between 500 and less than 2500 ppm (gas) LC50 between 2.0 and less than 10.0 (mg/l) (vapour) LC50 between 0.5 and less than 1.0 (mg/l) (dust, mist) Hazard statement Toxic if swallowed.
Language:English
Score: 1472649.4 - daccess-ods.un.org/acce...ST/SG/AC.10/C.4/2001/26&Lang=E
Data Source: ods
UPDATING OF THE 2ND REVISED EDITION OF THE GLOBALLY HARMONIZED SYSTEM OF CLASSIFICATION AND LABELLING OF CHEMICALS (GHS) : HEALTH HAZARDS : PROPOSAL FOR AMENDMENT OF TABLE 3.1.2 (CHAPTER 3.1) / TRANSMITTED BY THE EXPERT FROM GERMANY
Exposure routes Classification category or experimentally obtained acute toxicity range estimate (see Note 1) Converted Acute Toxicity point estimate (see Note 2) Oral (mg/kg bodyweight ) 0 Category 1 ≤ 5 5 Category 2 ≤ 50 50 Category 3 ≤ 300 300 Category 4 ≤ 2000 2000 Category 5 ≤ 5000 0.5 10 100 500 2500 Dermal (mg/kg bodyweight) 0 Category 1 ≤ 50 50 Category 2 ≤ 200 200 Category 3 ≤ 1000 1000 Category 4 ≤ 2000 2000 Category 5 ≤ 5000 5 70 300 1100 2500 Gases (ppmV) 0 Category 1 ≤ 100 100 Category 2 ≤ 500 500 Category 3 ≤ 2500 2500 Category 4 ≤ 20000 Category 5 - See footnote to 3.1.2.5. 10 140 700 4500 Vapours (mg/l) 0 Category 1 ≤ 0.5 0.5 Category 2 ≤ 2.0 2.0 Category 3 ≤ 10.0 10.0 Category 4 ≤ 20.0 Category 5 - See footnote to 3.1.2.5. 0.05 0.7 3 11 Dust/mist (mg/l) 0 Category 1 ≤ 0.05 0.05 Category 2 ≤ 0.5 0.5 Category 3 ≤ 1.0 1.0 Category 4 ≤ 5.0 Category 5 - See footnote to 3.1.2.5. 0.005 0.1 0.6 1.5 NOTE 2: These values are designed to be used in the calculation of the ATE for classification of a mixture based on its components and do not represent test results.
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Score: 1390850.4 - daccess-ods.un.org/acce...=ST/SG/AC.10/C.4/2008/4&Lang=E
Data Source: ods
DRAFT DECISION GUIDANCE DOCUMENT ON PERFLUOROOCTANE SULFONIC ACID, PERFLUOROOCTANESULFONATES, PERFLUOROOCTANESULFONAMIDES AND PERFLUOROOCTANESULFONYLS
K1282565 221012 UNITED NATIONS RC UNEP/FAO/RC/COP.6/10/Add.1 Rotterdam Convention on the Prior Informed Consent Procedure for Certain Hazardous Chemicals and Pesticides in
Language:English
Score: 1385314.1 - daccess-ods.un.org/acce...P/FAO/RC/COP.6/10/ADD.1&Lang=E
Data Source: ods