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REPORT OF THE UNITED NATIONS SCIENTIFIC COMMITTEE ON THE EFFECTS OF ATOMIC RADIATION
50 (482 p.) RAPPORT DU COBITE SCIENTIFIQUE DES NATIONS UNIES POUR L'ETUDE DES EFFETS DES RADIATIONS IONISANTES ASSEMBLEE GENERALE DOCUMENTS OFFICIELS : DIX-SEPTIEME SESSION SU PPLEMENT N° 16
Langue:Français
Ponctuation: 124547.07 - daccess-ods.un.org/acce...et?open&DS=A/5216(SUPP)&Lang=F
Source de données: ods
SECURITY COUNCIL OFFICIAL RECORDS, 17TH YEAR. SUPPLEMENT FOR OCTOBER, NOVEMBER AND DECEMBER 1962
SECURITY COUNCil OFFICIAL RECORDS SEVENTEENTH YEAR SUPPLEMENT FOR OCTOBER, NOVEMBER AND DECEMBER 1962 - CONSEIL DE SECURITE DOCUMENTS OFFICIELS DIX-SEPTI:i!ME ANNEE SUPPLEMENT D'OCTOBRE, NOVEMBRE
Langue:Français
Ponctuation: 63751.17 - https://daccess-ods.un.org/acc...en&DS=S/SUPP/1962/4(OR)&Lang=F
Source de données: ods
SECURITY COUNCIL OFFICIAL RECORDS, 20TH YEAR. SUPPLEMENT FOR JULY, AUGUST AND SEPTEMBER 1965
UN LIBRARY Ot t,; ') - .UN/ SA COLLECTION SECURITY COUNCIL. OFFICIAL RECORDS '.IWENTIEffl YEAR SUPPLEMENT FOR JULY, AUGUST AND SEPTEMBER 1965 CONSEIL DE SÉCURITÉ DOCUMENTS OFFICIELS
Langue:Français
Ponctuation: 28922.07 - https://daccess-ods.un.org/acc...t?open&DS=S/SUPP/1965/3&Lang=F
Source de données: ods
REVISION OF PARAGRAPH 2.8.3.2
During the discussions at the fifty-fourth session on the revision of paragraph 2.8.3.2, the following observations were made: (a) A substance or mixture resulting as non-classified based on OECD Test Guideline (TG) No 439 "In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method" may also be considered as non-corrosive to skin for the purposes of these Regulations without further new testing. (...) ST/SG/AC.10/C.3/2019/1 3 1 OECD Guideline for the testing of chemicals No. 404 "Acute Dermal irritation/Corrosion" 2015 2 OECD Guideline for the testing of chemicals No. 435 "In Vitro Membrane Barrier Test Method for Skin Corrosion" 2015 3 OECD Guideline for the testing of chemicals No. 431 "In Vitro Skin Corrosion: reconstructed human epidermis (RHE) test method" 2016 4 OECD Guideline for the testing of chemicals No. 430 "In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER)" 2015 5 OECD Guideline for the testing of chemicals No. 439 "In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method" 2015 Proposal 2 6. (...) If the in vitro test results indicate that the substance or mixture is corrosive, but the test method does not allow discrimination between packing groups I, II and III, it shall be considered to be packing group I.” 1 OECD Guidelines for the testing of chemicals No. 404 "Acute Dermal irritation/Corrosion" 2015; No. 435 "In Vitro Membrane Barrier Test Method for Skin Corrosion" 2015; No. 431 "In Vitro Skin Corrosion: reconstructed human epidermis (RHE) test method" 2016; and No. 430 "In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER)" 2015 2 OECD Guideline for the testing of chemicals No. 439 "In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method" 2015
Langue:Anglais
Ponctuation: 401.82 - https://daccess-ods.un.org/acc...=ST/SG/AC.10/C.3/2019/1&Lang=E
Source de données: ods
REVISED OECD TEST GUIDELINE 431 ALLOWING SUB-CATEGORISATION FOR SKIN CORROSION
OECD Test Guideline (TG) 431 "In vitro Skin Corrosion: Human Skin Model Test" was updated to introduce sub-categorisation for skin corrosion and adopted by the OECD in 2013 and further revised in 2014, 2015 and 2016, as TG 431 "In vitro skin corrosion: reconstructed human epidermis (RHE) test method". The in vitro methods included in TG 431 can now discriminate between GHS sub-category 1A and sub-category 1B/C. (...) The categorisation referred to is based on the classification criteria set out in the GHS, Rev. 7 (Table 3.2.1): Criteria Category 1 Destruction of skin tissue, namely, visible necrosis through the epidermis and into the dermis, in at least one tested animal after exposure ≤ 4 h Sub-category 1A Corrosive responses in at least one animal following exposure ≤ 3 min during an observation period ≤ 1 h Sub-category 1B Corrosive responses in at least one animal following exposure > 3 min and ≤ 1 h and observations ≤ 14 days Sub-category 1C Corrosive responses in at least one animal after exposures > 1 h and ≤ 4 h and observations ≤ 14 days 4. (...) A substance or mixture which is determined not to be corrosive in accordance with OECD Test Guideline 4303 4 or 4314 may be considered not to be corrosive to skin for the purposes of these Regulations without further testing. 1 OECD Guideline for the testing of chemicals No. 404 "Acute Dermal Irritation/Corrosion" 2015 2 OECD Guideline for the testing of chemicals No. 435 "In Vitro Membrane Barrier Test Method for Skin Corrosion" 2015 3 OECD Guideline for the testing of chemicals No. 431 "In Vitro Skin Corrosion: reconstructed human epidermis (RHE) test method" 2016 34 OECD Guideline for the testing of chemicals No. 430 "In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test (TER)" 2015 4 OECD Guideline for the testing of chemicals No. 431 "In Vitro Skin Corrosion: Human Skin Model Test" 2015”.
Langue:Anglais
Ponctuation: 374.52 - https://daccess-ods.un.org/acc...ST/SG/AC.10/C.3/2018/30&Lang=E
Source de données: ods
PROPOSAL FOR THE EDITORIAL REVISION OF CHAPTER 3.2 / SUBMITTED BY THE EXPERT FROM GERMANY ON BEHALF OF THE INFORMAL CORRESPONDENCE GROUP ON THE EDITORIAL REVISION OF CHAPTERS 3.2 AND 3.3
Table 3.2.1 Replace with the following: "Table 3.2.1 Skin corrosion category and sub-categories a Criteria Category 1 Destruction of skin tissue, namely, visible necrosis through the epidermis and into the dermis, in at least one tested animal after exposure ≤ 4 h Sub-category 1A Corrosive responses in at least one animal following exposure ≤ 3 min during an observation period ≤ 1 h Sub-category 1B Corrosive responses in at least one animal following exposure 3 min and ≤ 1 h and observations ≤ 14 days Sub-category 1C Corrosive responses in at least one animal after exposures 1 h and ≤ 4 h and observations ≤ 14 days “a The use of human data is addressed in 3.2.2.2 and in chapters 1.1 (para. 1.1.2.5(c)), and 1.3 (para. 1.3.2.4.7).” 3.2.2.1.2 Former 3.2.2.5 becomes new 3.2.2.1.2. (...) An example of a validated internationally accepted in vitro test method for skin irritation is OECD Test Guideline 439 (Reconstructed Human Epidermis Test Method); e Measurement of pH alone may be adequate, but assessment of acid or alkali reserve (buffering capacity) would be preferable. (...) Category 2 Warning Yes No 12 ST/SG/AC.10/C.4/2012/12 3.2.5.3.3 In the case of a study with 6 animals the following principles apply: (a) The substance or mixture is classified as skin corrosion Category 1 if destruction of skin tissue (that is, visible necrosis through the epidermis and into the dermis) occurs in at least one animal after exposure up to 4 hours in duration; (b) The substance or mixture is classified as skin irritation Category 2 if at least 4 out of 6 animals show a mean score per animal of ≥ 2.3 and ≤ 4.0 for erythema/eschar or for oedema; (c) The substance or mixture is classified as skin irritation Category 3 if at least 4 out of 6 animals show a mean score per animal of ≥ 1.5 and 2.3 for erythema/eschar or for oedema. 3.2.5.3.4 In the case of a study with 5 animals the following principles apply: (a) The substance or mixture is classified as skin corrosion Category 1 if destruction of skin tissue (that is, visible necrosis through the epidermis and into the dermis) occurs in at least one animal after exposure up to 4 hours in duration; (b) The substance or mixture is classified as skin irritation Category 2 if at least 3 out of 5 animals show a mean score per animal of ≥ 2.3 and ≤ 4.0 for erythema/eschar or for oedema; (c) The substance or mixture is classified as skin irritation Category 3 if at least 3 out of 5 animals show a mean score per animal of ≥ 1.5 and 2.3 for erythema/eschar or for oedema. 3.2.5.3.5 In the case of a study with 4 animals the following principles apply: (a) The substance or mixture is classified as skin corrosion Category 1 if destruction of skin tissue (that is, visible necrosis through the epidermis and into the dermis) occurs in at least one animal after exposure up to 4 hours in duration; (b) The substance or mixture is classified as skin irritation Category 2 if at least 3 out of 4 animals show a mean score per animal of ≥ 2.3 and ≤ 4.0 for erythema/eschar or for oedema; (c) The substance or mixture is classified as skin irritation Category 3 if at least 3 out of 4 animals show a mean score per animal of ≥ 1.5 and 2.3 for erythema/eschar or for oedema.” 13
Langue:Anglais
Ponctuation: 374.5 - daccess-ods.un.org/acce...ST/SG/AC.10/C.4/2012/12&Lang=E
Source de données: ods
REPORT OF THE SPECIALISTS APPOINTED BY THE SECRETARY-GENERAL TO INVESTIGATE ALLEGATIONS BY THE ISLAMIC REPUBLIC OF IRAN CONCERNING THE USE OF CHEMICAL WEAPONS
Desprendimiento cutáneo de la piel de la6 manos y separación de la epidermis en un 4OFI de la superficie corporal. Obstrucción traqueal. (...) Eritema y flictenas en la mano. Denudación de la epidermis en cara, tronco y brazos. Recuento de leucocitos 2.100. 31. (...) En la cara hay desprendimiento de la epidermis y costras. Eritema vinoso en todo el cuerpo.
Langue:Espagnol
Ponctuation: 366.37 - daccess-ods.un.org/acce...nsf/get?open&DS=S/16433&Lang=S
Source de données: ods
Besides that, the harvests may have light expressed color of the epidermis, as well and higher tolerances of other defficiencies. (...) The plums of this class may have smaller deviations from the shape and the color of the epidermis. Up to 10% of harvests without petiole are allowed. (...) The deviations with respect to development, the color of the epidermis and the firmness are tolerated. The berries with tye insignificant damages of the epidermis which do not influence on sustainability and organoleptic characteristics of the product are also tolerated.
Langue:Anglais
Ponctuation: 358.26 - https://www.wto.org/english/th.../cgr_e/WTACCCGR24A2_LEG_7c.pdf
Source de données: un
DRAFT AMENDMENTS TO THE GHS ADOPTED BY THE SUB-COMMITTEE AT ITS 21ST, 22ND AND 23RD SESSIONS : NOTE / BY THE SECRETARIAT
The text as amended in accordance with the editorial changes which were subsequently proposed by the informal working group on the revision of Chapters 3.2 and 3.3 is reproduced in document ST/SG/AC.10/C.4/2012/12 for consideration by the Sub-Committee. 5 ST/SG/AC.10/C.4/2012/29 3.2.5.3.3 In the case of a study with 6 animals the following principles apply: (a) The substance or mixture is classified as skin corrosion Category 1 if destruction of skin tissue (that is, visible necrosis through the epidermis and into the dermis) occurs in at least one animal after exposure up to 4 hours in duration; (b) The substance or mixture is classified as skin irritation Category 2 if at least 4 out of 6 animals show a mean score per animal of ≥ 2.3 ≤ 4.0 for erythema/eschar or for oedema; (c) The substance or mixture is classified as skin irritation Category 3 if at least 4 out of 6 animals show a mean score per animal of ≥ 1.5 2.3 for erythema/eschar or for oedema. 3.2.5.3.4 In the case of a study with 5 animals the following principles apply: (a) The substance or mixture is classified as skin corrosion Category 1 if destruction of skin tissue (that is, visible necrosis through the epidermis and into the dermis) occurs in at least one animal after exposure up to 4 hours in duration; (b) The substance or mixture is classified as skin irritation Category 2 if at least 3 out of 5 animals show a mean score per animal of ≥ 2.3 ≤ 4.0 for erythema/eschar or for oedema; (c) The substance or mixture is classified as skin irritation Category 3 if at least 3 out of 5 animals show a mean score per animal of ≥ 1.5 2.3 for erythema/eschar or for oedema. 3.2.5.3.5 In the case of a study with 4 animals the following principles apply: (a) The substance or mixture is classified as skin corrosion Category 1 if destruction of skin tissue (that is, visible necrosis through the epidermis and into the dermis) occurs in at least one animal after exposure up to 4 hours in duration; (b) The substance or mixture is classified as skin irritation Category 2 if at least 3 out of 4 animals show a mean score per animal of ≥ 2.3 ≤ 4.0 for erythema/eschar or for oedema; (c) The substance or mixture is classified as skin irritation Category 3 if at least 3 out of 4 animals show a mean score per animal of ≥ 1.5 2.3 for erythema/eschar or for oedema.”.]
Langue:Anglais
Ponctuation: 355.79 - daccess-ods.un.org/acce...ST/SG/AC.10/C.4/2012/29&Lang=E
Source de données: ods
IMPLEMENTATION CORROSIVITY CRITERIA OF GHS INTO CLASS 8 OF THE UN RECOMMENDATIONS ON THE TRANSPORT OF DANGEROUS GOODS / TRANSMITTED BY THE EXPERT FROM THE NETHERLANDS
Is a ‘response’ a full corrosive response as defined by “produces destruction of skin tissue, namely visible necrosis through the epidermis and into the dermis” or is any response (including a partial response) acceptable? (d) The definition of ‘skin’ in the Orange Book is not very clear as it can mean epidermis, dermis or both. The definition should be clarified. 3.
Langue:Anglais
Ponctuation: 345.73 - daccess-ods.un.org/acce...ST/SG/AC.10/C.3/2008/48&Lang=E
Source de données: ods