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GUIDELINES FOR TESTING DRUGS UNDER INTERNATIONAL CONTROL IN HAIR, SWEAT AND ORAL FLUID
The hair follicles extend from the dermis through the epidermis and the stratum corneum at the surface of the skin, and in humans, cover a high percentage of the body surface. (...) However, as the sample is commonly obtained by shaving, inherently, the specimen can be contaminated by pieces of epidermis. Similarly to scalp hair, beard hair may be contaminated by the external environment.
Language:English
Score: 754298.05 - daccess-ods.un.org/acce...open&DS=ST/NAR/30/REV.3&Lang=E
Data Source: ods
GLOBALLY HARMONIZED SYSTEM OF CLASSIFICATION AND LABELLING OF CHEMICALS (GHS). CHAPTERS 3.1-3.4
Skin Corrosion is the production of irreversible damage to the skin; namely, visible necrosis through the epidermis and into the dermis, following the application of a test substance for up to 4 hours1. (...) A corrosive is a test material that produces destruction of skin tissue, namely, visible necrosis through the epidermis and into the dermis, in 1 of 3 tested animals after exposure up to a 4 hour duration.
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Score: 730281.45 - daccess-ods.un.org/acce...ST/SG/AC.10/C.4/2001/22&Lang=E
Data Source: ods
CONSOLIDATED LIST OF AMENDMENTS RELEVANT FOR ADN ADOPTED BY THE JOINT RID/ADR/ADN MEETING AND BY THE WORKING PARTY ON THE TRANSPORT OF DANGEROUS GOODS (WP.15) FOR ENTRY INTO FORCE ON 1 JANUARY 2023
Add a footnote 10 to read “10 OECD Guideline for the testing of chemicals No. 439 “In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method” 2015”. (Reference document: ECE/TRANS/WP.15/AC.1/2021/24/Add.1) Renumber subsequent footnotes in Chapter 2.2 accordingly. 2.2.8.1.5.3 (c) (ii) Replace “ISO 3574 or Unified Numbering System (UNS) G10200 or a similar type” by “ISO 3574, Unified Numbering System (UNS) G10200”. 2.2.9.1.7 (g) Amend the beginning of the sentence to read “Except for button cells installed in equipment (including circuit boards), manufacturers ...”.
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Score: 721845.1 - https://daccess-ods.un.org/acc...RANS/WP.15/AC.2/2022/20&Lang=E
Data Source: ods
CONSOLIDATED LIST OF ADOPTED TEXTS
[Skin corrosion refers to the production of irreversible damage to the skin, namely, visible necrosis through the epidermis and into the dermis occurring after exposure to a substance or mixture.] [A substance is corrosive to skin when it leads to the destruction of skin tissue, namely, visible necrosis through the epidermis and into the dermis, in at least one tested animal after exposure for up to 4 hours.] 2.8.1.3 Liquids and solids which may become liquid during transport, which are judged not to be skin corrosive shall still be considered for their potential to cause corrosion to certain metal surfaces in accordance with the criteria in 2.8.3.3 (c) (ii). 2.8.2 General classification provisions 2.8.2.1 Substances and mixtures of Class 8 are divided among the three packing groups according to their degree of danger in transport: (a) Packing group I is assigned to very dangerous substances and mixtures; (b) Packing group II is assigned to substances and mixtures presenting medium danger; (c) Packing group III is assigned to substances and mixtures that present minor danger. 2.8.2.2 Allocation of substances listed in the Dangerous Goods List in Chapter 3.2 to the packing groups in Class 8 has been made on the basis of experience taking into account such additional factors as inhalation risk (see 2.8.2.4) and reactivity with water (including the formation of dangerous decomposition products). 2.8.2.3 New substances and mixtures can be assigned to packing groups on the basis of the length of time of contact necessary to produce [full thickness destruction of human skin] in accordance with the criteria in 2.8.3.
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Score: 694189.36 - https://daccess-ods.un.org/acc...ST/SG/AC.10/C.3/2016/55&Lang=E
Data Source: ods
CONSOLIDATED LIST OF AMENDMENTS RELEVANT FOR ADN ADOPTED BY THE JOINT RID/ADR/ADN MEETING AND BY THE WORKING PARTY ON THE TRANSPORT OF DANGEROUS GOODS (WP.15) FOR ENTRY INTO FORCE ON 1 JANUARY 2021
Insert a new footnote 7 as follows: “7 OECD Guideline for the testing of chemicals No. 431 “In vitro skin corrosion: reconstructed human epidermis (RHE) test method” 2016.”. At the end of the paragraph, add the following new sentence: “If the in vitro test results indicate that the substance or mixture is corrosive and not assigned to packing group I, but the test method does not allow discrimination between packing groups II and III, it shall be considered to be packing group II.”. 2.2.8.1.6.3.3 At the end, add the following new sentence: “For this calculation method, generic concentration limits apply where 1% is used in the first step for the assessment of the packing group I substances, and where 5% is used for the other steps respectively.”. 2.2.8.1.6.3.4 Delete the last sentence. 2.2.9.1.14, Note In footnote 11, remove “used as coolant”. 2.2.9.3 For M11, “Other substances and articles presenting a danger during carriage…”, after “3359 FUMIGATED CARGO TRANSPORT UNIT”, add “3363 DANGEROUS GOODS IN ARTICLES or”.
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Score: 686561.8 - https://daccess-ods.un.org/acc...RANS/WP.15/AC.2/2020/23&Lang=E
Data Source: ods
REPORT OF THE COMMITTEE OF EXPERTS ON THE TRANSPORT OF DANGEROUS GOODS AND ON THE GLOBALLY HARMONIZED SYSTEM OF CLASSIFICATION AND LABELLING OF CHEMICALS ON ITS EIGHTH SESSION - ADDENDUM
Chapter 3.2 3.2.1.1 Amend to read as follows: “Skin corrosion refers to the production of irreversible damage to the skin; namely, visible necrosis through the epidermis and into the dermis occurring after exposure to a substance or mixture.
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Score: 686561.8 - https://daccess-ods.un.org/acc...DS=ST/SG/AC.10/44/ADD.3&Lang=E
Data Source: ods
CONSOLIDATED LIST OF DRAFT AMENDMENTS
Add a footnote 5 to read “5 OECD Guideline for the testing of chemicals No. 439 “In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method” 2015”. (Reference document: ST/SG/AC.10/C.3/112/Add.1) 2.8.3.3 (c) (ii) Delete “or a similar type”.
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Score: 686561.8 - https://daccess-ods.un.org/acc...ST/SG/AC.10/C.3/2020/59&Lang=E
Data Source: ods
Fruit skin colour Measurement of the colouring of the epidermis of a fruit. Angle of bend The measured angle of bend.
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Score: 664688.5 - https://unece.org/fileadmin/DA...MeasuredAttributeCode_D09B.xsd
Data Source: un
REPORT OF THE AD HOC WORKING GROUP ON THE HARMONIZATION OF RID/ADR/ADN WITH THE UNITED NATIONS RECOMMENDATIONS ON THE TRANSPORT OF DANGEROUS GOODS-ADDENDUM-DRAFT AMENDMENTS TO RID/ADR/ADN PROPOSED BY THE AD HOC WORKING GROUP
Add a footnote 10 to read “10 OECD Guideline for the testing of chemicals No. 439 “In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method” 2015”. (RID:) 2.2.8.1.5.2 In the second sentence, replace “OECD Test Guidelines7,8,9,10” by “OECD Test Guidelines Nos. 4047, 4358, 4319 or 43010”. (...) Add a footnote 11 to read “11 OECD Guideline for the testing of chemicals No. 439 “In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method” 2015”. Renumber subsequent footnotes in Chapter 2.2 accordingly. 2.2.8.1.5.3 (c) (ii) Replace “ISO 3574 or Unified Numbering System (UNS) G10200 or a similar type” by “ISO 3574, Unified Numbering System (UNS) G10200”. 2.2.9.1.7 (g) Amend the beginning of the sentence to read “Except for button cells installed in equipment (including circuit boards), manufacturers ...”.
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Score: 661496.6 - https://daccess-ods.un.org/acc...P.15/AC.1/2021/24/ADD.1&Lang=E
Data Source: ods
REPORT OF THE SUB-COMMITTEE OF EXPERTS ON THE TRANSPORT OF DANGEROUS GOODS ON ITS FIFTY-SIXTH SESSION - ADDENDUM
Add a footnote 5 to read “5 OECD Guideline for the testing of chemicals No. 439 “In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method” 2015”. (Reference document: ST/SG/AC.10/C.3/2019/53) (replaces the amendment in the annex to document ST/SG/AC.10/C.3/110) 2.8.3.3 (c) (ii) Delete “or a similar type”.
Language:English
Score: 654567.2 - https://daccess-ods.un.org/acc.../SG/AC.10/C.3/112/ADD.1&Lang=E
Data Source: ods