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DERMAL EXPOSURE Substance diffuses through the skin layers into the blood circulation. a) Epidermis, b) Dermis, c) Hypodermis, d) Blood Vessels, e) Substance, f) Hair a b c d e f Considering both the likely physical form of the substances and the operational environments in which synthetic opioids are encountered, the highest risk exposure routes for officers are inhalation (where an airborne particulate is present) and injection.

GE.22-02124(E) Economic Commission for Europe Inland Transport Committee Working Party on the Transport of Dangerous Goods Agreement concerning the International Carriage of Dangerous

K1700936 140217 UNITED NATIONS BES IPBES/5/INF/20 Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services Distr.: General 7 February 2017

CERD/C/UZB/6-7 16 GE.10-41461 Per 100,000 persons 2005 2006 Total Women Total Women Acute intestinal infections 139.7 130.3 133.9 124.7 (including bacterial dysentery) 14.6 14.3 12.8 12.7 Viral hepatitis Total 115.8 110.3 112.9 108.9 Including: 0.0 0.0 Acute hepatitis-A 105.0 100.5 104.0 101.1 Acute hepatitis-В 8.9 8.2 7.3 6.4 Acute hepatitis-С 1.6 1.3 1.4 1.3 Airborne and droplet-borne infections Diphtheria - - - - Whooping-cough 0.5 0.5 0.4 0.4 Measles 2.8 2.7 3.2 2.8 German measles 1.7 1.5 1.1 0.9 Scarlet fever 3.5 2.9 3.4 3.2 Epidemic psittacosis 6.8 5.8 6.6 5.4 Chicken pox 15.5 14.6 16.2 14.9 Meningitis 0.2 0.2 0.3 0.2 Acute infections of the upper respiratory tract 2 267.6 2 100.9 2 110.1 1 957.4 Influenza 5.6 4.7 4.7 4.0 Naturally breeding infections and zooanthroponotic infections Siberian ulcers - - - - Tularaemia - - - - First-diagnosis brucellosis 2.2 0.9 1.8 0.9 Haemorrhagic fever - 0.0 0.0 0.0 Pediculosis 83.1 138.6 86.5 137.0 First-diagnosis malaria 0.4 0.3 0.3 0.2 Parasitic diseases Ascariasis 24.5 20.8 20.1 18.8 Trichuriasis 1.7 1.3 1.6 1.5 Enterobiosis 842.7 992.4 800.6 753.0 HIV 7.0 3.2 9.3 6.3 AIDS 0.0 0.0 0.0 0.0 CERD/C/UZB/6-7 GE.10-41461 17 Table 8 Morbidity by main categories of disease12 Per 100 000 population Total Women 2005 2006 2005 2006 Total recorded ailments 46 797.9 47 360.4 53 360.5 53 221.2 Including: Certain infectious and parasitic diseases 1 254.6 1 236.8 1 286.2 1 243.1 Neoplasms 185.3 176.4 221.4 199.4 Diseases of the endocrine system, dietary and digestive system disorders 2 825.7 2 644.7 3 570.3 3 236.6 Diseases of the blood and blood-producing organs and certain immune system disorders 8 253.5 8 555.9 11 627.4 12 008.3 Mental and behavioural disorders 220.5 208.1 122.5 114.6 Diseases of the nervous system 1 877.6 1 807.2 1 864.7 1 824.7 Diseases of the eye and its appendages 1 342.5 1 376.4 1 378.5 1 422.4 Diseases of the ear and mammiform appendix 1 145.3 1 240.4 1 158.5 1 264.1 Diseases of the circulatory system 1 451.4 1 541.8 1 438.5 1 528.8 Diseases of the respiratory organs 12 000.2 11 990.2 12 820.1 12 371.5 Diseases of the digestive organs 5 944.9 5 759.8 6 304.4 6 168.5 Diseases of the genito-urinary system 2 554.0 2 662.2 3 352.0 3 525.6 Diseases of the skin and epidermis 2 115.6 2 219.6 2 117.1 2 188.2 Diseases of the skeleto-muscular system and connective tissue 833.9 878.0 842.1 836.6 Congenital abnormalities (developmental defects), deformities and chromosome disorders 57.7 56.1 58.2 54.5 Symptoms, signs and deviations from the norm, unclassified under other headings and identified during clinical and laboratory tests 125.3 116.0 121.7 117.0 Trauma, poisoning and certain other effects of external causes 3 319.8 3 548.7 2 964.3 2 935.8 Table 9 Deaths, by main categories of cause (per 100,000 population)13 2005 2006 Total deaths from all causes 535.3 525.2 Including deaths from: Diseases of the circulatory system 301.3 304.1 Neoplasms 37.7 36.5 Accidents, poisoning, trauma 38.7 36.5 12 Data from the State Statistics Committee. 13 Data from the State Statistics Committee.

-(.\ lo ,) ~ SoS • \'1 .~ S tJ f r\. \6 ~'~$"'- f1 ~ --- REPORT OF THE UNITED NATIONS SCIENTIFIC UOMMITTEE ON THE EFFEUTS OF ATOMIC RADIATION GENERAL ASSEMBLY OFFICIAL .RECORDS: SEVENTEENTH

GE.15-05119 (E)  Committee on the Rights of the Child Consideration of reports submitted by States parties under article 44 of the Convention Second

GE.18-08746(E)  Economic Commission for Europe Administrative Committee of the European Agreement Concerning the International Carriage of Dangerous Goods by