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Importantly, many of the paediatric ARV formulations that are available are several times more expensive than the adult solid formulations. (...) In practice, given the current doses and formulations, the weight at which solid formulations should be offered will vary from around 10-12 kg depending on the ease of administration, acceptance and cost. (...) Then WHO/EDM, working with the regional offices, could then collaborate with relevant regional and national regulatory bodies in order to facilitate regulatory approval of new (or existing) paediatric ARV formulations including delivering regulatory advice on creating these formulations and advise on paediatric use of adult formulations.
Language:English
Score: 626762.6 - https://www.who.int/3by5/en/finalreport4Apr.pdf
Data Source: un
Furthermore, the VCLT contains no provisions on formal confirmation of conditional interpretative declarations formulated when signing a treaty or late formulation of an interpretative declaration, and nor has a uniform and widespread practice of States been established concerning these questions. (...) Guideline 2.3 Japan objects to late formulation of reservations going beyond the definition set out under the VCLT. (...) Japan has formulated objections to interpretative declarations formulated by another State in two cases.
Language:English
Score: 625733.1 - https://www.un.org/en/ga/sixth...dfs/statements/ilc/japan_2.pdf
Data Source: un
The DNA may use the incident data to submit a proposal under Article 6 of the Convention regarding severely hazardous pesticide formulations causing problems under conditions of use in a country. 1.3 What is a pesticide incident reporting system? (...) It includes: • pesticides available and in common use in the country – active ingredients and product formulations; • pesticide import and national sales statistics; preferably product specific; • types of crops treated. (...) Information on the characteristics of the product formulation, whether it was used as a powder or liquid, for instance should be included in this base line hazard information.
Language:English
Score: 622466.46 - https://www.fao.org/fileadmin/...s/Code/Incidentreporting09.pdf
Data Source: un
Slide 1 Increasing Access to pediatric ARV formulations Reaching out to children in '3by5' HIV care and treatment for children A technical consultation UNICEF/WHO Charlie Gilks, Director, Coordinator Treatment and Prevention Scale up HIV/AIDS Department, WHO Geneva Geneva, 3-4th Nov 2004 '3X5' -what do we mean? 3by5 is a target: 3 million on treatment by end 2005 The goal is universal access to ART as a human right The process is scale-up of national treatment action The challenges are to transform HIV/AIDS into a chronic disease and to accelerate HIV prevention making the intervention sustainable Delivering on 3 x 5 WHO and partners seek to catalyse rapid uptake of ART in communities where it is needed now but not widely accessible Supporting countries to recognise and respond to their HIV/AIDS treatment gap and leveraging the necessary resources to enable ART to be scaled up rapidly in line with 3x5 targets AND accelerate HIV prevention Simplifying and standardizing ART as far as possible without compromising effectiveness to enable widespread scale up and delivery in resource constrained settings • 15% of the global treatment burden is in children • ART works in children as well as in adults • But children are NOT getting on to treatment – Poor advocacy – Difficulties with diagnosis – Lack of appropriate formulations Understanding the Lack Of Access To Acceptable, Affordable And Appropriate ARV Formulations For Paediatric Use • No Fixed Dose Combinations (FDCs) available in paediatric formulations. • Of the few children who have access to treatment, almost all rely on adult capsules or tablets broken or mixed by parents or carers, dangerous under +/-over dosing. • Insufficient PK, PD or dosing data • No guidance on basic package of pead formulations, benchmarks for care or demand forecasting ART IN FIXED DOSE COMBINATIONS: ADULT AND PAEDIATRIC FORMULATIONS d4T + 3TC + NVP Adult Children FORMULATIONS Adult: d4T (30 mg or 40mg), 3TC 150mg, NVP 200 mg) Adult Children "Junior" (10 - 30 Kg):d4T 12mg, 3TC 60mg, NVP 100 mg Children "Baby" (3 – 10 Kg): d4T 6mg, 3TC 30mg, NVP 50mg '3X5' -what do we mean?
Language:English
Score: 621675.44 - https://www.who.int/3by5/en/1gilks.pdf
Data Source: un
Following the project formulation meeting (30 March) , six national scoping teams were established to kickstart the project formulation phase from March to July 2021. (...) The formulation reports were validated and finalized by end of July, which provides reference to the higher education institutions (HEI) in drafting their institutonal work plans. (...) From July to October 2021, the twelve partner HEIs will elaborate their institutional work plans with reference to the findings and recommendations of the formulation report, under the overall guidance of the national focal points, and in close collaboration with UNESCO.
Language:English
Score: 620160.6 - https://en.unesco.org/news/cfi...-formulation-phase-completed-6
Data Source: un
The workshops mark the completion of the project formulation phase in all six participating countries. Following the project formulation meeting in March 2021 , six national scoping teams were established to kickstart the project formulation phase from March to July 2021. (...) The formulation reports were validated and finalized by end of July, which provides reference to the higher education institutions in drafting their institutonal work plans.
Language:English
Score: 620160.6 - https://en.unesco.org/news/hig...-completed-6-african-countries
Data Source: un
Food and Drug Administration (FDA) to approve a dispersible 5 mg formulation of dolutegravir (DTG) for use in infants and children living with human immunodeficiency virus type 1 (HIV-1). (...) According to the FDA press release , 62% of pediatric patients taking the 5 mg formulation had an undetectable HIV viral load at 24 weeks and, at 48 weeks, 69% had an undetectable viral load. (...) The expedited development and introduction of optimal paediatric formulations is the central goal of global partnerships such as the WHO-led Global Accelerator for Paediatric Formulations (GAP-f).
Language:English
Score: 618144.63 - https://www.who.int/news/item/...young-children-living-with-hiv
Data Source: un
This policy was formulated through a consultative process and with technical support from FAO. (...) The FAO Right to Food Team was invited in 2011 to provide support to the formulation of the CARICOM Regional Action Plan to implement the Regional Food and Nutrition Security Policy. (...) The Right to Food Team’s work during the formulation stage of the Action Plan consisted in the first place in capacity strengthening of the formulation working group, focusing on creating an understanding among its members of right to food principles and of good governance practices.
Language:English
Score: 615189.2 - https://www.fao.org/right-to-f...lation-caricom-action-plan/ru/
Data Source: un
This policy was formulated through a consultative process and with technical support from FAO. (...) The FAO Right to Food Team was invited in 2011 to provide support to the formulation of the CARICOM Regional Action Plan to implement the Regional Food and Nutrition Security Policy. (...) The Right to Food Team’s work during the formulation stage of the Action Plan consisted in the first place in capacity strengthening of the formulation working group, focusing on creating an understanding among its members of right to food principles and of good governance practices.
Language:English
Score: 615189.2 - https://www.fao.org/right-to-f...lation-caricom-action-plan/en/
Data Source: un
This policy was formulated through a consultative process and with technical support from FAO. (...) The FAO Right to Food Team was invited in 2011 to provide support to the formulation of the CARICOM Regional Action Plan to implement the Regional Food and Nutrition Security Policy. (...) The Right to Food Team’s work during the formulation stage of the Action Plan consisted in the first place in capacity strengthening of the formulation working group, focusing on creating an understanding among its members of right to food principles and of good governance practices.
Language:English
Score: 615189.2 - https://www.fao.org/right-to-f...lation-caricom-action-plan/ar/
Data Source: un