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If skin irritation occurs, seek medical advice/ attention. Skin irritation (chapter 3.2) 2, 3 P333 + P313 If skin irritation or rash occurs: Get medical advice/attention. (...) If eye irritation persists, get medical advice/ attention.

ST/SG/AC.10/C.4/2006/9/Add.1 page 13 Hazard category Skin corrosion/irritation: Classification criteria (cont”d) 3 Mild irritant (applies to some authorities) 1. (...) Continued on next page ST/SG/AC.10/C.4/2006/9/Add.1 page 15 Hazard category Serious eye damage/eye irritation: Classification criteria (cont”d) 2A Irritant 1. (...) Continued on next page ST/SG/AC.10/C.4/2006/9/Add.1 page 16 Hazard category Serious eye damage/eye irritation: Classification criteria (cont”d) 2B Mild irritant 1.

There are also many substances and mixtures that have properties leading to classification with the following two hazard classes and categories: Skin corrosion/irritation, category 2: “Causes skin irritation” (H315) Serious eye damage/eye irritation, category 2B: “Causes eye irritation” (H320) In this case an appropriate hazard statement would be: “Causes skin and eye irritation” 14. As a final example, substances and mixtures may be classified for specific target organ toxicity, single exposure, category 3, in relation to either respiratory tract irritation, narcotic effects, or both. The relevant hazard statements are: “May cause respiratory irritation” (H335) “May cause drowsiness or dizziness” (H336) 15. (...) A second precedence rule can be added for the categories Skin corrosion/irritation 1A, 1B and 1C, and serious eye damage/eye irritation, category 1.

ST/SG/AC.10/C.4/2021/1 3 H315 + H320 “Causes skin and eye irritation” 13. The combined hazard statement: H315 + H320 “Causes skin and eye irritation” was introduced into Table A3.1.2 (see ST/SG/AC.10/C.4/2008/24) because many substances and mixtures have properties leading to classification with the following two hazard classes and categories: • Skin corrosion/irritation, category 2: “Causes skin irritation” (H315) • Serious eye damage/eye irritation, category 2B: “Causes eye irritation” (H320) 14. (...) Hence as serious eye damage/eye irritation, category 2/2A is more relevant the informal working group considered that it would be appropriate to replace the hazard statement H320 in the combined statement entry: H315 + H320 “Causes skin and eye irritation” in Table A3.1.2 with the hazard statement H319 “Causes serious eye irritation” as this hazard statement applies to hazard class and category of serious eye damage/eye irritation, category 2/2A. 16. (...) Code Health hazard statements Hazard class (GHS chapter) Hazard category (1) (2) (3) (4) H315 + H320 H319 Causes skin and serious eye irritation Skin corrosion/irritation (chapter 3.2) and serious eye damage/eye irritation (chapter 3.3) 2 (skin and eye)/2BA (eye) 17.

Toxicology in Vitro 2, 19-26. 3 Young J.R., How M.J. (1994), Product classification as corrosive or irritant by measuring pH and acid/alkali reserve. In Alternative Methods in Toxicology vol. 10 - In Vitro Skin Toxicology: Irritation, Phototoxicity, Sensitization, eds. A.Rougier, A.M. (...) (End of example) 8 ST/SG/AC.10/C.4/2012/25 Annex 3 [English only] Classification of a mixture for skin corrosion/irritation and serious eye damage/irritation following the tiered evaluation approach This example uses Serious Eye Damage/Eye Irritation in vitro data from a Bovine Corneal Opacity and Permeability (BCOP) test (OECD TG 437) to illustrate classification of a mixture following the proposed tiered evaluation approach in GHS Chapter 3.3.

Further information on skin irritation is required for those authorities that want to have more than one skin irritation category. (...) In addition, for most of these tests, irritating and corrosive effects need to be avoided. (...) The observation of skin irritation or the absence of skin irritating effects should be considered as not conclusive.

If bridging principles do not apply , classify as an irritant if: (a) For mixtures where substances can be added: the sum of concentrations of corrosive substances in the mixture is 1% but 5%; the sum of the concentrations of irritant substances is 10%; or the sum of (10 x the concentrations of corrosive ingredients) + ( the concentrations of irritant ingredients) is 10%; or (b) For mixtures where substances cannot be added: 3%. (...) If bridging principles do not apply , classify as mild irritant if: · For mixtures where substances can be added the sum of the concentrations of irritant substances in the mixture is 1% but 10%; · For mixtures where substances cannot be added: the sum of the concentrations of mild irritant substances is 10%; · the sum of (10 x the concentrations of corrosive substances) + (the concentrations of irritant substances) is 1% but 10%; or · the sum of (10 x the concentrations of corrosive substances) + (the concentrations of irritant substances) + (the concentrations of mild irritant substances ) is 10%. (...) If bridging does not apply , classify as an irritant (2A) if: (a) For mixtures where substances can be added: the sum of the concentrations of skin and/or eye Category 1 substances in the mixture is 1% but 3%; the sum of the concentrations of eye irritant substances is 10%; or the sum of (10 x the concentrations of skin and/or eye category 1 substances) + ( the concentrations of eye irritants) is 10% (b) For mixtures where substances cannot be added: the sum of the concentrations of eye irritant ingredients is 3% (See 3.3.3.3.4) Hazard statement Causes serious eye irritation Symbol No symbol Signal word Warning 2B Mild Irritant 1.

(See paragraph 25) Hazard statement Causes skin irritation ST/SG/AC.10/C.4/2001/26 page 23 Hazard category Criteria Hazard communication elements Signal word Warning Symbol None 3 Mild Irritant (applies to some authorities) 1. (...) I bridging principles do not apply, classify as mild irritant if: • For mixtures where substances can be added the sum of the concentrations of irritant substances in the mixture is 1% but 10%; • For mixtures where substances cannot be added: the sum of the concentrations of mild irritant substances is 10%; • the sum of (10 x the concentrations of corrosive substances) + (the concentrations of irritant substances) is 1% but 10%; or • the sum of (10 x the concentrations of corrosive substances) + (the concentrations of irritant substances) + (the concentrations of mild irritant substances ) is 10%. (...) If bridging does not apply, classify as an irritant (2A) if: For mixtures where substances can be added:: the sum of the concentrations of skin and/or eye Category 1 substances in the mixture is 1% but 3%; the sum of the concentrations of eye irritant substances is 10%; or the sum of (10 x the concentrations of of skin and/or eye category 1 substances) + ( the concentrations of eye irritants) is 10% For mixtures where substances cannot be added: the sum of the concentrations of eye irritant ingredients is 3% (See paragraph 27) Hazard statement Causes severe eye irritation Signal word Warning Symbol No symbol 2B Mild Irritant 1.

(b) The substance or mixture is classified as eye irritation Category 2A if at least 3 out of 5 animals show a mean score per animal of: (i) ≥ 1 for corneal opacity and/or (ii) ≥ 1 for iritis and/or (iii) ≥ 2 for conjunctival redness and/or (iv) ≥ 2 for conjunctival oedema (chemosis) and which fully reverses within an observation period of normally 21 days. (...) (b) Classification as eye irritation Category 2A if at least 3 out of 4 animals show a mean score per animal of: (i) ≥ 1 for corneal opacity and/or (ii) ≥ 1 for iritis and/or (iii) ≥ 2 for conjunctival redness and/or (iv) ≥ 2 for conjunctival oedema (chemosis) and which fully reverses within an observation period of normally 21 days. (c) The substance or mixture is classified as mildly irritating to eyes (Category 2B) if the effects listed in sub-paragraph (b) above are fully reversible within 7 days of observation.”.]

Grey smoke, garlic smell D. Irritated eyes, noee, throat, skin, with cough E. 12 April 1987 / . . . (...) Rurning eyes and nose, irritated throat and skin F d. 26 January 1987 / . . . (...) No flash or explosion (3 . Irritating smell D. Lachrymation, pain and irritation in eyes, cough with yellowish-red expectoration, shortnees of hreath, tightness in chest, unconscious for 30 minuten E . 9 Apri 1 1987 Med ica 1. cond it ion : -- General condition .