Home

Results 51 - 60 of 2,576 for irritable. Search took 3.785 seconds.  
Sort by date/Sort by relevance
REVISION OF PARAGRAPH 2.8.3.2
The TG provides an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with GHS Category 2. (...) ST/SG/AC.10/C.3/2019/1 3 1 OECD Guideline for the testing of chemicals No. 404 "Acute Dermal irritation/Corrosion" 2015 2 OECD Guideline for the testing of chemicals No. 435 "In Vitro Membrane Barrier Test Method for Skin Corrosion" 2015 3 OECD Guideline for the testing of chemicals No. 431 "In Vitro Skin Corrosion: reconstructed human epidermis (RHE) test method" 2016 4 OECD Guideline for the testing of chemicals No. 430 "In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER)" 2015 5 OECD Guideline for the testing of chemicals No. 439 "In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method" 2015 Proposal 2 6. (...) If the in vitro test results indicate that the substance or mixture is corrosive, but the test method does not allow discrimination between packing groups I, II and III, it shall be considered to be packing group I.” 1 OECD Guidelines for the testing of chemicals No. 404 "Acute Dermal irritation/Corrosion" 2015; No. 435 "In Vitro Membrane Barrier Test Method for Skin Corrosion" 2015; No. 431 "In Vitro Skin Corrosion: reconstructed human epidermis (RHE) test method" 2016; and No. 430 "In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER)" 2015 2 OECD Guideline for the testing of chemicals No. 439 "In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method" 2015
Language:English
Score: 1019833.8 - https://daccess-ods.un.org/acc...=ST/SG/AC.10/C.3/2019/1&Lang=E
Data Source: ods
ASSESSING THE POTENTIAL DEVELOPMENT OF A GLOBAL LIST OF CHEMICALS CLASSIFIED IN ACCORDANCE WITH THE GLOBALLY HARMONIZED SYSTEM OF CLASSIFICATION AND LABELLING OF CHEMICALS
Liq. 3; H226 for liquid DCPD (see Note 1) 2.7 Flammable solids Not classified Data lacking 2.8 Self-reactive substances Not classified Hazard class not applicable 2.9 Pyrophoric liquids Not classified Hazard class not applicable 2.10 Pyrophoric solids Not classified Hazard class not applicable 2.11 Self-heating substances Not classified Hazard class not applicable 2.12 Substances which in contact with water emit flammable gases Not classified Hazard class not applicable 2.13 Oxidising liquids Not classified Hazard class not applicable 2.14 Oxidising solids Not classified Hazard class not applicable 2.15 Organic peroxides Not classified Hazard class not applicable 2.16 Corrosive to metals Not classified Data lacking 2.17 Desensitized explosives Not classified Hazard class not applicable 3.1 Acute toxicity - via oral route Acute Tox. 3; H301 - via dermal route Acute Tox. 5; H313 - via inhalation route Acute Tox. 2; H330 3.2 Skin corrosion/irritation Skin Irrit. 2; H315 3.3 Serious eye damage/eye irritation Not classified Data conclusive but not sufficient for classification 3.4 Respiratory sensitisation Not classified Data lacking Skin sensitisation Not classified Data conclusive but not sufficient for classification 3.5 Germ cell mutagenicity Not classified Data conclusive but not sufficient for classification 3.6 Carcinogenicity Not classified Data lacking 3.7 Reproductive toxicity Repr.2; H361 (developmental toxicity) 3.8 Specific target organ toxicity- single exposure STOT SE 3; H335, H336 3.9 Specific target organ toxicity- repeated exposure STOT RE 2; H373 3.10 Aspiration hazard Asp. (...) Hazard class not applicable * Note 1: Above 32.2 °C/90° F, the pure substance is a liquid as also commercial grades with purity < 97% at room temperature ST/SG/AC.10/C.3/2017/7 ST/SG/AC.10/C.4/2017/1 5 DCPD proposed labelling Pictogram code(s): GHS02 (Flame), GHS06 (Skull and crossbones), GHS08 (Health hazard), GHS09 (Environment) Signal word: Danger Hazard statement code(s): H226: Flammable liquid and vapour [for liquid DCPD] H301: Toxic if swallowed H304: May be fatal if swallowed and enters airways H313: May be harmful in contact with skin H315: Causes skin irritation H330: Fatal if inhaled H335: May cause respiratory irritation H336: May cause drowsiness and dizziness H361: Suspected of damaging the unborn child H373: May cause damage to organs through prolonged or repeated exposure via oral and inhalation routes of exposure H400: Very toxic to aquatic life H411: Toxic to aquatic life with long lasting effects Supplemental information: According to 1.4.10.5.3.1 (a) if the skull and crossbones applies, the exclamation mark should not appear. (...) ST/SG/AC.10/C.3/2017/7 ST/SG/AC.10/C.4/2017/1 6 DMTC draft classification and labelling DMTC proposed classification and reason for not proposing a classification for a hazard class GHS Chapter Hazard class Proposed classification (Hazard class and category; Hazard statement code(s)) Proposed specific concentration limits (SCL(s)) and M-factor(s) Reason for no proposed classification* 2.1 Explosives No classification Data lacking 2.2 Flammable gases No classification Hazard class not applicable 2.3 Aerosols No classification Hazard class not applicable 2.4 Oxidising gases No classification Hazard class not applicable 2.5 Gases under pressure No classification Hazard class not applicable 2.6 Flammable liquids No classification Hazard class not applicable 2.7 Flammable solids No classification Data conclusive but not sufficient for classification 2.8 Self-reactive substances No classification Data lacking 2.9 Pyrophoric liquids No classification Hazard class not applicable 2.10 Pyrophoric solids No classification Data lacking 2.11 Self-heating substances No classification Data conclusive but not sufficient for classification 2.12 Substances which in contact with water emit flammable gases No classification Data lacking 2.13 Oxidising liquids No classification Hazard class not applicable 2.14 Oxidising solids No classification Data lacking 2.15 Organic peroxides No classification Hazard class not applicable 2.16 Corrosive to metals No classification Data lacking 2.17 Desensitized explosives No classification Hazard class not applicable 3.1 Acute toxicity - via oral route Acute Tox. 3; H301 - via dermal route Acute Tox. 3; H311 - via inhalation route Acute Tox. 2; H330 3.2 Skin corrosion/irritation Skin Corr. 1; H314 3.3 Serious eye damage/eye irritation Eye Dam. 1; H318 3.4 Respiratory sensitisation No classification Data lacking.
Language:English
Score: 1019009.7 - https://daccess-ods.un.org/acc...=ST/SG/AC.10/C.3/2017/7&Lang=E
Data Source: ods
IMPROVEMENT OF THE PRESENTATION OF ANNEXES 1 AND 2 OF THE GHS / TRANSMITTED BY THE EXPERT FROM SWEDEN ON BEHALF OF THE INFORMAL CORRESPONDENCE GROUP ON THE IMPROVEMENT OF ANNEXES 1, 2 AND 3 OF THE GHS
UN b May not be acceptable for transport in the packaging in which it is tested (See Chapter 2.5, par. 2.5.3.2.2 of the U Model Regulations). 11 ST/SG/AC.10/C.4/2012/22 A1.16 Corrosive to metals (see Chapter 2.16 for classification criteria) Classification Labelling Pictogram Hazard class Hazard category GHS UN Model Regulations Signal word Hazard statement Code Corrosive to metals 1 Warning May be corrosive to metals H290 A1.17 Acute toxicity (see Chapter 3.1 for classification criteria) Classification Labelling Pictogram Hazard class Hazard category GHS UN Model Regulationsa Signal word Hazard statement Code Oral Fatal if swallowed H300 Dermal Fatal in contact with skin H310 1 Inhalation Danger Fatal if inhaled H330 Oral Fatal if swallowed H300 Dermal Fatal in contact with skin H310 2 Inhalation Danger Fatal if inhaled H330 Oral Toxic if swallowed H301 Dermal Toxic in contact with skin H311 3 Inhalation Danger Toxic if inhaled H331 Oral Harmful if swallowed H302 Dermal Harmful in contact with skin H312 4 Inhalation Not required Warning Harmful if inhaled H332 Oral May be harmful if swallowed H303 Dermal May be harmful in contact with skin H313 Acute toxicity 5 Inhalation No pictogram Not required Warning May be harmful if inhaled H333 a For gases, under the UN Recommendations on the Transport of Dangerous Goods, Model Regulations, replace the number “6” in the bottom corner of the pictogram by “2”. 12 ST/SG/AC.10/C.4/2012/22 A1.18 Skin corrosion/irritation (see Chapter 3.2 for classification criteria) Classification Labelling Pictogram Hazard class Hazard category GHS UN Model Regulations Signal word Hazard statement Code 1 Corrosive (including A, B and C) Danger Causes severe skin burns and eye damage H314 2 Irritant Not required Warning Causes skin irritation H315 Skin corrosion/irritation 3 Mild irritanta No pictogram Not required Warning Causes mild skin irritation H316 a Applies to some authorities. A1.19 Serious eye damage/eye irritation (see Chapter 3.3 for classification criteria) Classification Labelling Pictogram Hazard class Hazard category GHS UN Model Regulations Signal word Hazard statement Code 1 Irreversible effects Not required Danger Causes serious eye damage H318 2/2A Irritant Not required Warning Causes serious eye irritation H319 Serious eye damage/eye irritation 2B Mild irritant No pictogram Not required Warning Causes eye irritation H320 13 ST/SG/AC.10/C.4/2012/22 A1.20 Respiratory sensitization (see Chapter 3.4 for classification criteria) Classification Labelling Pictogram Hazard class Hazard category GHS UN Model Regulations Signal word Hazard statement Code 1 Not required Danger May cause allergy or asthma symptoms or breathing difficulties if inhaled H334 1Aa Not required Danger May cause allergy or asthma symptoms or breathing difficulties if inhaled H334 Respiratory sensitization 1Ba Not required Danger May cause allergy or asthma symptoms or breathing difficulties if inhaled H334 a Sub-categories may be applied where data are sufficient and where required by a competent authority. A1.21 Skin sensitization (see Chapter 3.4 for classification criteria) Classification Labelling Pictogram Hazard class Hazard category GHS UN Model Regulations Signal word Hazard statement Code 1 Not required Warning May cause an allergic skin reaction H317 1Aa Not required Warning May cause an allergic skin reaction H317 Skin sensitization 1Ba Not required Warning May cause an allergic skin reaction H317 a Sub-categories may be applied where data are sufficient and where required by a competent authority. 14 ST/SG/AC.10/C.4/2012/22 A1.22 Germ cell mutagenicity (see Chapter 3.5 for classification criteria) Classification Labelling Pictogram Hazard class Hazard category GHS UN Model Regulations Signal word Hazard statement Code 1 (both 1A and 1B) Not required Danger May cause genetic defects (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard) H340 Germ cell mutagenicity 2 Not required Warning Suspected of causing genetic defects (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard) H341 A1.23 Carcinogenicity (see Chapter 3.6 for classification criteria) Classification Labelling Pictogram Hazard class Hazard category GHS UN Model Regulations Signal word Hazard statement Code 1 (both 1A and 1B) Not required Danger May cause cancer (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard) H350 Carcinogenicity 2 Not required Warning Suspected of causing cancer (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard) H351 15 ST/SG/AC.10/C.4/2012/22 A1.24 Toxic to reproduction (see Chapter 3.7 for classification criteria) Classification Labelling Pictogram Hazard class Hazard category GHS UN Model Regulations Signal word Hazard statement Code 1 (both 1A and 1B) Not required Danger May damage fertility or the unborn child (state specific effect if known) (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard) H360 2 Not required Warning Suspected of damaging fertility or the unborn child (state specific effect if known) (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard) H361 Toxic to reproduction Additional category for effects on or via lactation No pictogram Not required No signal word May cause harm to breast-fed children H362 16 ST/SG/AC.10/C.4/2012/22 A1.25 Specific target organ toxicity following single exposure (see Chapter 3.8 for classification criteria) Classification Labelling Pictogram Hazard class Hazard category GHS UN Model Regulations Signal word Hazard statement Code 1 Not required Danger Causes damage to organs (or state all organs affected, if known) (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard) H370 2 Not required Warning May cause damage to organs (or state all organs affected, if known) (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard) H371 Specific target organ toxicity following single exposure 3 Not required Warning May cause respiratory irritation or May cause dizziness or drowsiness H335 H336 A1.26 Specific target organ toxicity following repeated exposure (see Chapter 3.9 for classification criteria) Classification Labelling Pictogram Hazard class Hazard category GHS UN Model Regulations Signal word Hazard statement Code 1 Not required Danger Causes damage to organs (state all organs affected, if known) through prolonged or repeated exposure (state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard) H372 Specific target organ toxicity following repeated exposure 2 Not required Warning May cause damage to organs (state all organs affected, if known) through prolonged or repeated exposure(state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard) H373 17 ST/SG/AC.10/C.4/2012/22 A1.27 Aspiration hazard (See chapter 3.10 for classification criteria) Classification Labelling Pictogram Hazard class Hazard category GHS UN Model Regulations Signal word Hazard statement Code 1 Not required Danger May be fatal if swallowed and enters airways H304 Aspiration hazard 2 Not required Warning May be harmful if swallowed and enters airways H305 18 ST/SG/AC.10/C.4/2012/22 A1.28 (a) Short-term (acute) hazards to the aquatic environment (see Chapter 4.1 for classification criteria) Classification Labelling Pictogram Hazard class Hazard category GHS UN Model Regulationsa Signal word Hazard statement Code Acute 1 Warning Very toxic to aquatic life H400 Acute 2 No pictogram Not required No signal word Toxic to aquatic life H401 Short-term (Acute) hazards to the aquatic environment Acute 3 No pictogram Not required No signal word Harmful to aquatic life H402 a For category 1, under the UN Recommendations on the Transport of Dangerous Goods, Model Regulations, the pictogram is not required if the substance presents any other hazards covered by UN Model Regulations.
Language:English
Score: 1017402.1 - daccess-ods.un.org/acce...ST/SG/AC.10/C.4/2012/22&Lang=E
Data Source: ods
CLASSIFICATION CRITERIA FOR HEALTH HAZARDS AND HAZARDS TO THE ENVIRONMENT (INCLUDING MIXTURES) / TRANSMITTED BY THE ORGANIZATION FOR ECONOMIC CO-OPERATION AND DEVELOPMENT (OECD)
Authorities wanting to have two hazard classes can use both irritant and mild irritant classes. PURPOSE, BASIS AND APPLICABILITY 50. (...) From the training set, about 0.34 of the chemicals are in the mild irritant class, and the total is the sum of the proportion of irritants and mild irritants, or 0.68 of the chemicals. 63. (...) Test materials in the irritant class would be excluded from being placed in the mild irritant class.
Language:English
Score: 1017263.9 - daccess-ods.un.org/acce...ST/SG/AC.10/C.4/2001/11&Lang=E
Data Source: ods
HIGHLIGHTS OF THE REPORT ON THE PILOT PROJECT ON ASSESSING THE POTENTIAL DEVELOPMENT OF A GLOBAL LIST OF CLASSIFIED CHEMICALS
This discussion took place in the context of classification proposal for DCPD for Acute Oral Toxicity, where using the mouse study is more conservative. (d) Irritation - There are differences in reporting and interpretation of the scores for skin and eye irritation. For example, in the case of dibutyl phthalate, the scores for skin and eye irritation in one study were given as primary dermal irritation index (PDII) scores: 0.54/8 for skin irritation and 0.11/110 for eye irritation. (...) To ensure consistency and transparency between classifications in the future, there should be consensus on the reporting and interpretation of irritation scores. For example, the result of a skin irritation study of DBP on the ECHA site is given as follows: "After 4 and 24 hours very slight (grade 1) erythema were observed for 2/3 animals.
Language:English
Score: 1016227.4 - daccess-ods.un.org/acce...ST/SG/AC.10/C.4/2016/18&Lang=E
Data Source: ods
HEALTH HAZARDS : CLARIFICATION OF CHAPTER 3.2, SKIN CORROSION/IRRITATION / TRANSMITTED BY THE EXPERT FROM SWEDEN
GENERAL ST/SG/AC.10/C.4/2004/23 29 September 2004 Original: ENGLISH COMMITTEE OF EXPERTS ON THE TRANSPORT OF DANGEROUS GOODS AND ON THE GLOBALLY HARMONIZED SYSTEM OF CLASSIFICATION AND LABELLING OF CHEMICALS Sub-Committee of Experts on the Globally Harmonized System of Classification and Labelling of Chemicals Eighth session, 6-9 December 2004 Item 2(b) of the provisional agenda UPDATING OF THE GLOBALLY HARMONIZED SYSTEM OF CLASSIFICATION AND LABELLING OF CHEMICALS (GHS) Health hazards Clarification of Chapter 3.2, Skin Corrosion/Irritation Transmitted by the expert from Sweden 1. At the 7th Session of the Sub-Committee, the expert from Sweden introduced a paper (UN/SCEGHS/7/INF.11) suggesting that the Sub-Committee look further into the issue of classification of substances and mixtures which may not show an irritating or corrosive property in their dry state but may produce skin corrosion or irritation in contact with moist skin or mucous membranes. 2. (...) GE.04-23739 ST/SG/AC.10/C.4/2004/23 page 2 At the end of Section 3.2.2.2, add the following note: NOTE : Whereas liquid substances are tested neat, solid substances should be ground to fine powder and evaluated in the presence of water or an appropriate solvent in order to determine if irritation or corrosion may result when the solid substance is in contact with moist skin or mucous membranes. ___________________
Language:English
Score: 1015389.5 - daccess-ods.un.org/acce...ST/SG/AC.10/C.4/2004/23&Lang=E
Data Source: ods
COMMUNICATION FROM MR. JULIUS K. NYERERE CONCERNING TANGANYIKA
Here was an opportunity for Government to invite the confidence of the people by removing this irritation which it was a public secret, Government was only n few months ago willing to remove. (...) Here was I, the so-culled Agitator and Racialist, in effect su~gesting to Government how these objects could be achieved without irritating the Ch:i.efs and their people. I must protest against this unwise and unnecessary irritation of the Chiefs and the people. (...) These artificial and unnecessary racial irritations ·may be intei.1ded to delay and may result in delaying the ·achievement of democra.tic Self-Government.
Language:English
Score: 1015055.4 - https://daccess-ods.un.org/acc...et?open&DS=T/COM.2/L.45&Lang=E
Data Source: ods
GE.13-20089 Commi
• In the last box of the decision logic (page 12 of the English version of the document) delete “for which” in the first sentence, so that it reads: “Does the mixture contain one or more corrosive or irritant ingredients4 when the additivity approach…” (remainder of the text unchanged). (...) • In Table A1.19, under “Hazard category”, delete “Irreversible effects”, “Irritant” and “Mild irritant”. • In Table A1.24 replace “Toxic to reproduction” with “Reproductive toxicity” in the title and under the heading “Hazard class” (...) For the group of hazard classes “Acute toxicity (dermal)”, “Skin corrosion”, “skin irritation”, “skin sensitisation”, “severe eye damage” and “eye irritation”: in the condition for use, replace “Manufacturer/supplier or the competent authority to specify type of equipment” with “Manufacturer/supplier or the competent authority may further specify type of equipment where appropriate”.
Language:English
Score: 1012653.8 - daccess-ods.un.org/acce...T/SG/AC.10/C.4/48/ADD.1&Lang=E
Data Source: ods
However, we should not allow emotions to control us, so that, for example, we do not hurt ourselves or others because of anger, sadness or irritation. Learning to be aware of your anger and to express it in a safe way is an important part of good mental health. (...) However, if you are not sure why you attacked someone, think about what happened during the day that made you feel so irritated. If you are going through a difficult period in life, it is even more important to deal with your anger so that it does not have devastating consequences on your health and relationships with other people.
Language:English
Score: 1012492.4 - https://www.unicef.org/serbia/...%20to%20Manage%20Anger_web.pdf
Data Source: un
.: – Less lethal agents such as irritants – Toxic industrial materials such as chlorine, hydrogen fluoride or other acids – Chemical or biological warfare agents – Radiologicals Impact on soft targets - examples Ghabili, K., Agutter, P., S., Ghanei, M., Ansarin, K. (...) Terrorists` current capabilities Improvised explosive devices on UAS already established – Not only as improvised explosive devices, also for surveillance and reconnaissance May be enhanced by CBRN materials Levels of technology for CBRN attacks Low level technology – Easily available toxic industrial materials such as chlorine, stolen radioactive sources, hoaxes, irritants, simple equipment for delivery, small UAVs Medium level technology – „Home made“ crude chemical warfare agents, also using outdated processes, toxins, sophisticated CBRN IEDs, crude biologicals like anthrax, military assets and ammunition available, small to medium UAVs for delivery High level technology, potentially also state-sponsored – Biological weapons, radiologicals, wide range of chemical warfare agents, all sizes of UAS including drones and drone swarms, advanced military capabilities (e.g. missiles, rockets, mortars, high sophisticated improvised explosive devices) Enhancing UAS with CBRN payloads: Typical means of dispersal and dissemination Explosives for dispersal (including modified military ordnance) – Bombs, bomblets, dispensers – Grenades, mines, mortars – Missiles, rockets – Pyrotechnic dispersal Bulk containers, cylinders Dispersal devices without explosives – Gas released from cylinders – Spraying devices – Binary systems producing toxic substances Low level technology: Spraying devices on small to medium size UAS Spray tanks Spray Tanks are holding some hundred litres of chemical materials or a wet slurry of biologicals Systems may be either pressurized e.g. with a nitrogen bottle or unpressurized and dispenses the contents (up to 100l/second) Spray tanks can be mounted on high performance aircraft, cruise missiles, drones, etc.
Language:English
Score: 1012492.4 - https://www.un.org/counterterr...ovoden_-_unoct_consultant_.pdf
Data Source: un