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  ghsc06.PDF

Step Parameter Finding Conclusion Negative response or no data 6 Valid and accepted in vitro dermal irritation test f) Positive response Classify as irritant a) Negative response or no data 7 In vivo dermal corrosion test (1 animal) Corrosive response Classify as corrosive a) Negative response 8 In vivo dermal irritation test (3 animals total) h) Irritant response Classify as irritant a) Negative response No further testing Classify as irritant a) 9 When it is ethical to perform human patch testing g) Irritant response Classify as irritant a) Not as above Non-irritant response No further testing a. (...) From the training set, about 0.34 of the chemicals are in the mild irritant category, and the total is the sum of the proportion of irritants and mild irritants, or 0.68 of the chemicals. 13. (...) Test materials in the irritant category would be excluded from being placed in the mild irritant category.

Score: 1434197.9 - https://www.ilo.org/legacy/eng...fework/ghs/ghsfinal/ghsc06.pdf

  ghsc07.PDF

Figure 1: Testing and evaluation strategy for eye irritation/corrosion (see also: “Testing and evaluation strategy for skin irritation/corrosion”). (...) Step 9: Only two animals may be employed for irritation testing (including the one used for evaluation of possible severe effects) if these two animals give concordant clearly irritant or clearly non-irritant responses. (...) Those authorities desiring one single category for classification of “eye irritation” may use the overall harmonised Category 2 (irritating to eyes): others may want to distinguish between Category 2 (irritating to the eyes) and Category 2A (mildly irritating to eyes). 7 Table 2: Reversible Eye Effects Categories.

Score: 1427677.4 - https://www.ilo.org/legacy/eng...fework/ghs/ghsfinal/ghsc07.pdf

  4.31 Triforine (T)**

The LC 50 in rats exposed by inhalation was >5.1 mg/l. Triforine was not irritating or sensitizing to the skin of rodents and was minimally irritating to the eyes of rabbits. (...) Toxicological criteria for estimation of guidance values for dietary and non-dietary exposure to triforine Human exposure Relevant route, study type, species Results, remarks Short-term (1-7 days) Oral, single dose, rat LD 50 > 5000 mg/kg bw Dermal, single dose, rat LD 50 > 2000 mg/kg bw Inhalation (4h), rat LC 50 5.1 mg/l Dermal, irritation, rabbit Not irritating Ocular, irritation, rabbit Minimally irritating Dermal, irritation, rat Not irritating Dermal, sensitization, guinea-pig Non-sensitizing Medium-term (1-26 weeks) Dermal, 3 weeks, rat NOAEL = 1100 mg/kg bw per day (highest dose tested) Oral, 13 weeks, dog NOAEL = 3.6 mg/kg bw per day: haemosiderin deposition NOAEL = 1500 mg/kg bw per day: reproductive toxicity Oral, two-generation, reproductive toxicity, rat NOAEL = 49 mg/kg bw per day: parental and offspring toxicity NOAEL = 5 mg/kg bw per day: maternal toxicity Oral, developmental toxicity, rabbit NOAEL = 125 mg/kg bw per day: fetal and developmental toxicity Long-term ( ³ 1 year) Oral, 2 years, dog NOAEL = 2.4 mg/kg bw per day: haematological changes; haemosiderin deposition; haematopoiesis

Score: 1270383.5 - https://www.fao.org/3/w8141e/w8141e18.htm

  FEAT 2.0 POCKET GUID

Corr. 1, Liquid Toxic liquid Acute Tox. 1 Allyl alcohol [2-Propen-l-ol] 107-18-6 Aquatic Acute 1, Acute Tox. 1, Acute Tox. 2, Acute Tox. 3, Eye Irrit. 2, Eye Irrit. 2A, Skin Irrit. 2, STOT RE 1, STOT SE 3, Flam. (...) Liq. 3, Liquid Health hazard Carc. 1A - Ethylene oxide [Oxirane] 75-21-8 Aquatic Chronic 3, Acute Tox. 2, Acute Tox. 3, Carc. 1B, Eye Irrit. 2, Eye Irrit. 2A, Muta. 1B, Skin Irrit. 2, STOT RE 1, STOT SE 3, Flam. (...) Liq. 3, Liquid Toxic liquid Acute Tox. 2 - Methyltrichlorosilane [Silane, trichloromethyl-] 75-79-6 Eye Irrit. 2, Skin Corr. 1A, Skin Irrit. 2, STOT SE 3, Flam.

Score: 1260988.7 - https://www.unocha.org/sites/u...iles/FEAT%20Pocket%20Guide.pdf

  Risk Phrases Used in the Countries of EU - International occupational safety & health information ce

R35 Causes severe burns. R36 Irritating to eyes. R37 Irritating to respiratory system. (...) R27/28 Very toxic in contact with skin and if swallowed. R36/37 Irritating to eyes and respiratory system. R36/38 Irritating to eyes and skin. R36/37/38 Irritating to eyes, respiratory system and skin. R37/38 Irritating to respiratory system and skin.

Score: 1255209.7 - www.ilo.org/legacy/engl...products/safetytm/clasann2.htm

  Deliberate events: Chemical release and oil fires

These include upper respiratory tract and skin irritation; runny nose; cough; shortness of breath; eye, nose, and throat irritation; and aggravation of sinus and asthma conditions. (...) Chemical weapons can be irritants, choking agents, disabling chemicals, blistering agents, nerve agents, or asphyxiants. (...) Exposure may relatively quickly result in eye irritation, coughing, hoarseness and mild irritation to the skin, but often the severe effects of exposure, including characteristic blistering, are delayed for several hours.

Score: 1245506.6 - https://www.who.int/news-room/...berate-events-chemical-release

  list_e.doc

Diseases caused by ozone, phosgene 1.1.31. Diseases caused by irritants: benzoquinone and other corneal irritants 1.1.32.Diseases caused by any other chemical agents not mentioned in the preceding items 1.1.1 to 1.1.31, where a link between the Exposure of a worker to these chemical agents and the diseases suffered is established 1.2. (...) Occupational asthma caused by recognized sensitizing agents or irritants inherent to the work process 2.1.5. Extrinsic allergic alveolitis caused by the inhalation of organic dusts, as prescribed by national legislation 2.1.6. (...) Upper airways disorders caused by recognized sensitizing agents or irritants inherent to the work process 2.1.10. Any other respiratory disease not mentioned in the preceding items 2.1.1 to 2.1.9, caused by an agent where a direct link between the exposure of a worker to this agent and the disease suffered is established 4 2.2.

Score: 1213065.4 - https://www.ilo.org/wcmsp5/gro...eetingdocument/wcms_116841.pdf

  Responses of the Rep

Police officers in their work, act in accordance with the Law on Police[footnoteRef:3], which in Article 105 defines, among other things, the following means of coercion: an irritant spray, electromagnetic and chemical agents. [3: RS Official Gazette“, No.6/16,24/18 and 87/18] Also, the Police Act defines that an irritant spray and electromagnetic means can be used on a group of persons, as well as what the use of a coercive agent entails: - the use of a spray with an irritant means the use of spray doses filled with tear gas or a chemical substance of а milder effect than tear gas, that is, a specially designed substance with an intolerable odor; - the use of electromagnetic means is considered the use of electro-shockers and electric batons, which emit an electromagnetic pulse of short-term effect; -use of chemical agents is considered the use of tear gas for short-term use and chemical substances of milder effect than tear gas, which upon the termination of effect do not leave consequences for psychophysical and general health.

Score: 1210251.9 - https://www.ohchr.org/sites/de...efulProtest/States/serbia.docx

  4.7 Chlormequat (T)

Chlormequat was not irritating to the skin or eye in rabbits. It did not cause delayed contact hypersensitivity when tested in albino guinea-pigs by the method of Buehler or by the method of Magnusson and Kligman. (...) Toxicological criteria for setting guidance values for dietary and non-dietary exposure to chlormequat Human exposure Relevant route, study type, species Results, remarks Short-term (1-7 days) Dermal irritation, rabbit Not irritating Eye irritation, rabbit Not irritating Skin sensitization, guinea-pig Non-sensitizing Inhalation toxicity, rat LC 50 > 5 mg/l air Dermal toxicity, rabbit LD 50 > 1300 mg/kg bw Oral toxicity, rabbit LD 50 = 70 mg/kg bw Oral toxicity, cat LD 50 = 7-50 mg/kg bw Medium-term (1-26 weeks) Repeated oral, reproductive toxicity, rabbit NOAEL = 6 mg/kg bw per day: maternal toxicity, no reproductive toxicity Long-term ( ³ one year) Repeated oral, one year, dog NOAEL = 4.7 mg/kg bw per day: diarrhoea, vomiting and salivation

Score: 1208999.6 - https://www.fao.org/3/w8141e/w8141e0k.htm

  4.15 Fipronil (T)*

Animals at 1.5 ppm, predominantly females, showed irritability, vocalization, salivation, aggression, hyperactivity, and bruxism. (...) Two studies of primary dermal irritation in rabbits were performed. Fipronil was a slight irritant when moistened with corn oil before application but was not irritating when moistened with water before application. Fipronil was a slight irritant in two studies of primary ocular irritation in rabbits.

Score: 1201486 - https://www.fao.org/3/w8141e/w8141e0s.htm