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The researchers will screen the compounds against wildtype and mutant C. elegans strains to elucidate the compounds’ mechanisms of action. 15 2013 AZ McGill AZ will provide McGill University researchers with approximately 10,000 diverse compounds to screen against C. elegans. (...) A CDC researcher will provide information about primers to use for this diagnostic. 36 2013 Eskitis AZ The Eskitis Institute will provide AZ Bangalore researchers with samples from its Nature Bank to screen against M. tuberculosis. 37 2014 Eskitis Swiss TPH The Eskitis Institute will provide a Swiss TPH researcher with samples from its Nature Bank to screen against helminths and schistosomes. 38 2012 GSK CWHM GSK will provide CWHM researchers with information, data, and insights into the development of MetAp-1 inhibitors for tuberculosis. 39 2012 GSK UW GSK will work collaboratively with a UW researcher to identify the lead compound in a series, originally from the TCAMS. 40 2012 GSK UW A UW researcher will provide GSK with confidential information and compounds. (...) Once completed, a USF researcher will assess the device’s ability to concentrate Ascaris eggs from soil and sewage samples. 118 2017 USF U Yaoundé I A USF natural products chemist will attempt to isolate, characterize, and elucidate the structures of several fractions and pure compounds from Cameroonian fungi and medicinal plants.
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Score: 1086782 - https://www.wipo.int/export/si...s/collaboration_agreements.pdf
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TDR also has played a pioneering role in establishing win-win agreements with industry, obtaining compounds from pharmaceutical and animal health companies to support lead discovery through a coordinated network of compound assessment centres. (...) Hits emerging from such screens are assessed in whole parasites (in vitro) through the compound screening network. In addition, compounds (small molecules and natural products) are sourced and channeled into the compound screening network for whole-cell screening, with actives subsequently tested in animal disease models. (...) For example, 10 000 compounds were purchased this year from Life Chemicals.
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Score: 1064481.9 - https://www.who.int/tdr/public...nts/bl3-annual-report-2008.pdf
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Similar data show normal outcomes in 124 pregnancies exposed to artemisinin compounds in the 1st trimester. These numbers are too small to provide an adequate profile of the safety of these compounds when used to treat malaria in pregnancy. (...) Presently, artemisinin compounds cannot be recommended for treatment of malaria in the 1st trimester. (...) Robalo AFRO e-mail: robalom@whoafr.org Assessment of the safety of artemisinin compounds in pregnancy 16
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Score: 1054717.9 - https://www.who.int/tdr/public...n-compounds-pregnancy-2003.pdf
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PharmaMar has recognized the richness of this chemical diversity and is actively involved in the discovery and development of marine-derived bioactive compounds as innovative treatments for cancer. After almost two decades of bioprospection and research, PharmaMar has built up a unique collection of marine invertebrates and microorganisms and has discovered many new families of bioactive compounds with novel chemical structures. Such novel chemical structures often result in new modes of action against tumour cells, thereby further enhancing the potential utility of such marine-derived compounds as therapeutic agents. PharmaMar has five compounds in clinical development and an exciting drug discovery and development pipeline. (...) The presentation will provide an overview of how PharmaMar has successfully used Bioprospection to discover and develop Innovative BioActive Compounds to enhance Cancer care.
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Score: 1047455 - https://www.un.org/Depts/los/c.../documents/8_abstract_munt.pdf
Data Source: un
What is known • What is known – 3427 species of marine flora and fauna – 143 genera from deep sea • What is unknown – Specimens collected, yet to be identified – ~1 million species yet to be discovered 3 Experiences in collections • Research laboratories – Port Henderson – Hofstra – Port Royal – Discovery Bay • Expeditions – Eastward and Gosnold (1960/70) – Research institute from Florida (1990’s) • On going collections – Locally (Ascidians) – Overseas Genetic Resources Policy • NEPA has responsibility for access to genetic resources • Protected, endangered & endemic sp - CITES, require MTA • No Material Transfer Agreement for non- endemic sp • No policy to regulate access to genetic resources (draft Bio-safety policy 75% complete) 4 Relevant Institutions Institute of Jamaica • Taxonomic Collection • Scientific focal point of CBD University of the West Indies •Centre for Marine Sciences •Life Sciences Dept •Marine laboratories •Chemistry Dept •Biotechnology Centre •Natural Products Institute NGOs •Montego Bay Marine Park •Northern Jamaica Conservation Association Private Sector Harvesting of Sea Squirts • Through agreement with PharmaMar. • Supply 500 kg of the ascidians, frozen and shipped • One shipment made, analogue of the active compound subsequently synthesized Contained compounds called ecteinascidins Useful in alleviating certain childhood cancers, leukemia and the treatment for inflammatory conditions Ecteinascidia turbinata 5 ICBG Programme New Drugs from Marine Natural Resources from Jamaica reefs Project (UMISS/UWI) Medicinal potential for marine life in Jamaican coral reefs, has the potential to bring important pharmaceuticals to the market place. (...) –Filing of a US Utility Patent Application based on materials collected in Jamaica Application unsuccessful due to degraded status of Jamaica’s reefs Restoration of Coral Reefs • In association with the National Institute of Oceanography in Haifa, Israel • Reef building coral species susceptible to bleaching • Extract DNA from the zooxanthallae • Corals with resistant strains used for rehabilitation • Training to take place in Israel in 2008 6 Other on going activities • Teaching - DNA extraction - sea urchin and seagrass (teaching methodology) • Research -Chemical assays of marine algae, fungi, sponges, gorgonians • Collection - by overseas researchers, extraction of bioactive compounds from sponges Challenges • Limited knowledge about marine biodiversity, – deep sea and – extensive EEZ, – lack of expertise in species identification – Limited knowledge of invasive species • Limited capacity – Facilities – Training/knowledge/technology – research – commercialization 7 Challenges (cont’d) • Limited experience with access and benefit sharing, mistrust • Illegal removal of organisms • Threat to the livelihood of resources users Opportunities • For various types of research – Taxonomic/inventory – Biological/Ecological – Relatedness of species and adaptation potential • To discover bioactive compounds – Treat and cure diseases – Food, health and cosmetic etc – Economic benefits • Natural resource management, and enforcement and public awareness & education • Collaboration/private investment 8 Marcia M.
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Score: 1040762.3 - https://www.un.org/Depts/los/c...process/documents/8_creary.pdf
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Tributyl tin-based products, once used extensively, are now banned because of their now well-known impact on sex determination in marine molluscs and other organisms. Naturally derived antifoulants include enzymes, antimicrobials, biomimetics such as novel topographies, and natural chemical signals (Callow and Callow, 2011; Kirschner and Brennan, 2012; Gittens et al., 2013) Marine algae are an important source of novel antifouling compounds and mangroves and sponges also feature high on the list of exploited marine organisms. (...) Such identified active natural compounds inspire the commercial synthesis of mimetics that are more stable and easily applied to surfaces, such as ship hulls, docks etc. (...) Mayer et al. (2010) note that the pre-clinical pipeline “continues to supply several hundred novel marine compounds every year and those continue to feed the clinical pipeline with potentially valuable compounds.”
Language:English
Score: 1034962.9 - https://www.un.org/depts/los/g...rting/WOA_RPROC/Chapter_29.pdf
Data Source: un
We also have a special responsibility to advance environmental preservation because we have the privilege of working on this wonderful campus. The UNON compound is not only one of the most beautiful and forested UN offices in the world; it also hosts the global HQs of UNEP and UN-Habitat, which play such key roles in promoting sustainable development and creating a healthier balance between nature and humanity. (...) This is an important step and will require major efforts on the part of all UN entities on the compound. Additionally, efforts are underway to increase the amount of waste recycled from the offices and other operations at UNON, including through the purchase of recycling and waste separation bins for the compound. (...) UNON has signed a partnership with UNEP for the implementation of a pilot project on wastewater treatment at the compound. This will start with an assessment of the facilities and the collection of water data.
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Score: 1030058.3 - https://www.unon.org/sites/www...for_world_environment_day.docx
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This contributing paper analyses systemic risk and compound vulnerabilities, by highlighting a case study to help decision-makers formulate effective strategies to address the nature of systemic risks in their societies. (...) A common theme of each of the spotlight areas is that close attention needs to be paid to compound vulnerabilities such as regional manifestations of armed conflict and (mal)adaptive forms of human mobility to conflict hotspots to understand systematic risk from a changing climate perspective for food security. As the era of hazard-by-hazard risk reduction comes to an end, there is a need to better understand the systemic nature of risk. Share this Go back Also featured on PreventionWeb Download Systemic risks emerging from compound vulnerabilities Download file (1.18 MB/PDF) Related information Related links Horn of Africa drought: Late rains in Ethiopia, Kenya and Somalia are inflaming hunger, warns WFP Addressing the climate-conflict nexus: Evidence, insights, and future directions How can climate finance work better for fragile and conflict-affected regions?
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Score: 1028796.2 - https://www.undrr.org/publicat...rging-compound-vulnerabilities
Data Source: un
The group was working together to collect and classify plants used by natural healers to treat malaria, and to scientifically identify active compounds that could be used to develop new malaria drugs. The research project was set up by TDR to both develop research capacity in Kenya and find new compounds. Survivors Guide is a documentary series that focuses on how individuals are taking charge of their lives. This programme profiles Jack Githae, a natural healer outside Nairobi, who has had a life-long passion for raising the profile and science of traditional remedies.
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Score: 1028479.1 - https://www.who.int/tdr/news/2...8/bbc-natural-plants-video/en/
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No in vivo data on the compounds have been reported and no attempts appear to have been made to obtain the compounds synthetically. (...) Nitroimidazoles (see pages 23-24) Commercial interest in this series of compounds is influenced by both Novartis and th PathoGenesis Corporation abandoning their lead compounds CGI 17341 and PA824/PA1343. (...) Calanolides Calanolide A is a naturally occurring pyranocoumarin66 of considerable interest because of its dual activity against TB and HIV infections.67,68 The compound, an inhibitor of HIV-1 reverse transcrip- tase,69 is being progressed by Sarawak MediChem Pharmaceuticals and is in Phase I/II development stage for the HIV indication.
Language:English
Score: 1024619.4 - https://www.who.int/tdr/public...ons/documents/anti-tb-drug.pdf
Data Source: un