Dadu2x2
Vitamin D
Vitamin E
Vitamin K
KALIUM
FOLAT
NATRIUM
Kalsium
Magnesium
FOSFOR
SENG
BESI
IODIUM
Vitamin B1
Vitamin B2
Vitamin B3
Vitamin B5
Vitamin B6
Vitamin B12
Language:English
Score: 1082732.9
-
https://www.unicef.org/indonesia/id/media/8816/file
Data Source: un
0
Vitamin A Supplementation: Market and Supply Update
UNICEF Supply Division
June 2018
1
Vitamin A Supplementation
Market and Supply Update – June 2018
1. (...) UNICEF procures vitamin A mostly as retinol, which is the animal form of vitamin A, with a
minimum shelf-life of 24 months. (...) The
trend in WAP reflects the impact of vitamin A API on the world market price, as most vitamin A
API is destined for other uses in human and animal nutrition.
Language:English
Score: 1079622.4
-
https://www.unicef.org/supply/...n-market-and-supply-update.pdf
Data Source: un
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Press release
Over 140 million children at greater risk of illness as they miss life-saving vitamin A supplements
UNICEF urges immediate action as vitamin A coverage declines alarmingly, most starkly in West and Central Africa
02 May 2018
UNICEF/UN048391/Pirozzi
A girl receives a dose of vitamin A at a basic health centre in Khan Pur Baga Sher Village, in Muzaffargarh District in Punjab Province.
(...) But in 26 countries with the highest rates of child mortality – where vitamin A supplementation programmes are needed most – 62 million children missed vitamin A supplements in 2016, triple the number missed in 2015.
(...) At the same time, the report notes that until children have access to nutritious and safe diets that protect them from vitamin A deficiency, vitamin A supplementation programmes remain essential in many countries.
Language:English
Score: 1072818.7
-
https://www.unicef.org/turkey/en/node/2531
Data Source: un
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e-Library of Evidence for Nutrition Actions (eLENA)
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eLENA
A-Z list of interventions
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Life course
Nutrients
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About eLENA
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Nutrients
Fruit and vegetables are excellent sources of vitamins and minerals
WHO/Lori Sloate
Several nutrients – including water – are essential for growth, reproduction and good health.
Macronutrients are consumed in relatively large quantities and include proteins, carbohydrates, and fats and fatty acids.
Micronutrients – vitamins and minerals – are consumed in relatively smaller quantities, but are essential to body processes.
Carbohydrates
Fibre
Increasing fruit and vegetable consumption to reduce the risk of noncommunicable diseases
Sugars
Reducing consumption of sugar-sweetened beverages to reduce the risk of childhood overweight and obesity
Reducing consumption of sugar-sweetened beverages to reduce the risk of unhealthy weight gain in adults
Reducing free sugars intake in adults to reduce the risk of noncommunicable diseases
Reducing free sugars intake in children to reduce the risk of noncommunicable diseases
Fats and fatty acids
Long chain polyunsaturated fatty acid supplementation during pregnancy
Protein
Balanced energy and protein supplementation during pregnancy
Vitamins and minerals
Calcium
Calcium supplementation during pregnancy to reduce the risk of pre-eclampsia
Folate
Daily iron and folic acid supplementation during pregnancy
Daily iron and folic acid supplementation during pregnancy in malaria-endemic areas
Intermittent iron and folic acid supplementation during pregnancy
Intermittent iron and folic acid supplementation during pregnancy in malaria-endemic areas
Intermittent iron and folic acid supplementation in adult women and adolescent girls
Intermittent iron and folic acid supplementation in adult women and adolescent girls in malaria-endemic areas
Iron supplementation with or without folic acid to reduce the risk of postpartum anaemia
Iron supplementation with or without folic acid to reduce the risk of postpartum anaemia in malaria-endemic areas
Periconceptional folic acid supplementation to prevent neural tube defects
Iodine
Iodine supplementation in pregnant and lactating women
Iodization of salt for the prevention and control of iodine deficiency disorders
Iron
Daily iron and folic acid supplementation during pregnancy
Daily iron and folic acid supplementation during pregnancy in malaria-endemic areas
Daily iron supplementation in adult women and adolescent girls
Daily iron supplementation in children 24–59 months of age
Daily iron supplementation in children 24–59 months of age in malaria-endemic areas
Daily iron supplementation in children 6-23 months of age
Daily iron supplementation in children 6-23 months of age in malaria-endemic areas
Daily iron supplementation in children and adolescents 5–12 years of age
Daily iron supplementation in children and adolescents 5–12 years of age in malaria-endemic areas
Intermittent iron and folic acid supplementation during pregnancy
Intermittent iron and folic acid supplementation during pregnancy in malaria-endemic areas
Intermittent iron and folic acid supplementation in adult women and adolescent girls
Intermittent iron and folic acid supplementation in adult women and adolescent girls in malaria-endemic areas
Intermittent iron supplementation in preschool and school-age children
Intermittent iron supplementation in preschool and school-age children in malaria-endemic areas
Iron supplementation with or without folic acid to reduce the risk of postpartum anaemia
Iron supplementation with or without folic acid to reduce the risk of postpartum anaemia in malaria-endemic areas
Potassium
Increasing potassium intake to control blood pressure in children
Increasing potassium intake to reduce blood pressure and risk of cardiovascular diseases in adults
Sodium
Iodization of salt for the prevention and control of iodine deficiency disorders
Reducing sodium intake to control blood pressure in children
Reducing sodium intake to reduce blood pressure and risk of cardiovascular diseases in adults
Vitamin A
Vitamin A fortification of staple foods
Vitamin A supplementation during pregnancy
Vitamin A supplementation in children 6–59 months of age with severe acute malnutrition
Vitamin A supplementation in children with respiratory infections
Vitamin A supplementation in HIV-infected adults
Vitamin A supplementation in HIV-infected infants and children 6–59 months of age
Vitamin A supplementation in HIV-infected women during pregnancy
Vitamin A supplementation in infants 1–5 months of age
Vitamin A supplementation in infants and children 6–59 months of age
Vitamin A supplementation in neonates
Vitamin A supplementation in postpartum women
Vitamin B6
Vitamin B6 supplementation during pregnancy
Vitamin C
Vitamin E and C supplementation during pregnancy
Vitamin D
Vitamin D supplementation and respiratory infections in children
Vitamin D supplementation during pregnancy
Vitamin D supplementation in infants
Vitamin E
Vitamin E and C supplementation during pregnancy
Vitamin E supplementation for the prevention of morbidity and mortality in preterm infants
Zinc
Zinc supplementation and growth in children
Zinc supplementation during pregnancy
Zinc supplementation in children with respiratory infections
Zinc supplementation in the management of diarrhoea
Micronutrients
Biofortification of staple crops
Fortification of maize flour and corn meal
Fortification of rice
Fortification of wheat flour
Micronutrient intake in children with severe acute malnutrition
Micronutrient supplementation in HIV-infected women during pregnancy
Micronutrient supplementation in individuals with active tuberculosis
Micronutrient supplementation in low-birth-weight and very-low-birth-weight infants
Multiple micronutrient powders for point-of-use fortification of foods consumed by children 2-12 years of age
Multiple micronutrient powders for point-of-use fortification of foods consumed by children 6–23 months of age
Multiple micronutrient powders for point-of-use fortification of foods consumed by pregnant women
Multiple micronutrient supplementation during pregnancy
Water
Water, sanitation and hygiene interventions to prevent diarrhoea
Multiple nutrients
Balanced energy and protein supplementation during pregnancy
Increasing fruit and vegetable consumption to reduce the risk of noncommunicable diseases
Macronutrient supplementation in people living with HIV/AIDS
Supplemental nutrition with dietary advice for older people affected by undernutrition
Supplementary feeding in community settings for promoting child growth
Supplementary foods for the management of moderate acute malnutrition in children aged 6 - 59 months
Therapeutic feeding of children 6–59 months of age with severe acute malnutrition and acute or persistent diarrhoea
Transition feeding of children 6–59 months of age with severe acute malnutrition
Contact us
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© 2022
WHO
Language:English
Score: 1072495.7
-
https://www.who.int/elena/nutrient/en/
Data Source: un
S0000225
A multiple micronutrient powder (MNP) supplement containing 15 essential vitamins and minerals in the base of a carrier,with
customised labeling. (...) Supplement containing 15 essential vitamins and minerals in the
base of a carrier. Each sachet weighs 1gram, supplied in boxes or pouches of 30 sachets. (...) Supplement containing 15 essential vitamins and minerals in the
base of a carrier. Each sachet weighs 1gram, supplied in boxes or pouches of 30 sachets.
Language:English
Score: 1070227.9
-
https://www.unicef.org/supply/...0suppliers%20-%20nutrition.pdf
Data Source: un
Main results
4.1 Included studies
Five randomized controlled trials, enrolling 7528 HIV-infected women, were included in this review
Four studies were placebo-controlled, while one study compared vitamin A supplementation to standard care
Four trials supplemented women in the antenatal period; two of these trials also supplemented women randomized to vitamin A treatment with high dose vitamin A (200,000 IU) at delivery, and in another study all women received 100,000 IU at six weeks’ postpartum, as per standard care in the region. Oral daily doses of vitamin A ranged from 3000 to 10,000 IU, and women were additionally supplemented with beta-carotene from 0 to 30 mg/day
One trial was conducted in the postpartum period only, supplementing women with a single high dose of vitamin A (400,000 IU) or placebo, and also supplemented infants with a single high dose of vitamin A (50,000 IU) or placebo in a 2 x 2 factorial design
Co-interventions included iron, folic acid and multivitamins; however, the use of antiretroviral agents was not well reported
4.2 Study settings
Malawi, South Africa, the United Republic of Tanzania, and Zimbabwe (2 trials)
Vitamin A deficiency in pregnant women was a moderate to severe public health problem in all included countries, as estimated in the WHO Global Database on Vitamin A Deficiency (2009)
4.3 Study settings
How the data were analysed Vitamin A supplementation of HIV-infected women during pregnancy or the postpartum period was compared to placebo control or standard care. (...) Subgroup analyses were conducted by timing of maternal vitamin A supplementation, i.e., in the antenatal or postpartum period.
Language:English
Score: 1069658.8
-
https://www.who.int/elena/titl...ies/vitaminA-pregnancy-hiv/en/
Data Source: un
The objectives of the VMNIS are to:
Systematically retrieve and summarize data on vitamin and mineral status of populations.
Provide Member States with up-to-date national, regional, and global assessments of the magnitude of vitamin and mineral deficiencies.
(...) Download
Read More
30 May 2011
Serum retinol concentrations for determining the prevalence of vitamin A deficiency in populations
This document aims to provide users of the Vitamin and Mineral Nutrition Information System (VMNIS) with information about the use of serum retinol for...
(...) Download
Read More
11 May 2009
Global prevalence of vitamin A deficiency in populations at risk 1995-2005 : WHO global database on vitamin...
Language:English
Score: 1068633.6
-
https://www.who.int/teams/nutr...l-nutrition-information-system
Data Source: un
Also, when there is a,
❑ change of production site
❑ significant change in production equipment
or process (e.g. heat treatment)
❑ modification of an existing product
❑ change in primary packaging material
❑ change of formulation or major ingredient,
such as, but not limited to:
i. raw material
ii. vitamins & minerals premix
iii. emulsifier
❑ change in supplier-only for vitamins &
minerals premix and Vitamin A*
* MSF & UNICEF additional requirement
INTERAGENCY
REQUIREMENTS FOR STABILITY STUDY
When Stability Study
is needed (2/2)
❑ Real time (long term) stability study should
be conducted :
➢ at 30°C±2°C with 65% RH (if
applicable) for the duration of the shelf life, and
➢ at 40°C±2°C with 75% RH (if
applicable) for the duration of the shelf life
❑ Testing period and time points:
➢ minimum testing frequency : T0, T3, T6,
T12, T18 and T24 months and then
yearly for both temperatures
❑ Stability should be conducted on, at least 1
representative batch (prefer 2 batches*)
* UNICEF additional requirement
INTERAGENCY
REQUIREMENTS FOR STABILITY STUDY
Type of stability studies required
For Real Time Stability Study
Minimum
protocol requirements
❑ Accelerated stability study should be
conducted :
➢ at 40°C±2°C with 75% RH (if
applicable)
❑ Testing period and time points:
➢ minimum testing frequency : T0, T1, T2,
T3 and T6 months
❑ Stability should be conducted on, at least 1
representative batch (prefer 2 batches*)
* UNICEF additional requirement
INTERAGENCY
REQUIREMENTS FOR STABILITY STUDY
Type of stability studies required
For Accelerated Stability Study
Minimum
protocol requirements
❑ Stability batch should be,
➢ Commercial batch size (Preferred*)
➢ Process validated (Preferred*)
➢ Produced with the same vitamins & minerals
premix and / or Vitamin A, source to be used
in the commercial finished product
➢ Manufactured ONLY by the product
manufacturer
➢ Pilot scale batch MAY be accepted, subject to
prior approval only
➢ For Pilot scale batch-method of manufacture
and procedure MUST simulate the final
process to be used for production batches
* UNICEF additional requirement
INTERAGENCY
REQUIREMENTS FOR STABILITY STUDY
Stability Batch Size
Minimum requirements
❑ Monitoring of relative humidity is not
mandatory
❑ If the shelf life study is performed in an
incubator
✓ Relative humidity must be set at 65%
and 75%.
✓ RH (Relative Humidity) can vary ±5%*
❑ Temperature and relative humidity (if
applicable) must be regularly controlled and
recorded.
❑ The record of calibration of incubator(s) shall
be available upon request.
* UNICEF additional requirement
INTERAGENCY
REQUIREMENTS FOR STABILITY STUDY
Relative Humidity (RH)
Minimum requirements
❑ All the tests shall be performed in ISO17025
accredited laboratories (Preferred)
❑ Stability studies must verify the following
parameters
❑ Micronutrient stability:
✓ Minimum 1 water soluble vitamin (vitamin C
mandatory) shall be tested at every test point
✓ Minimum 1 fat soluble vitamin shall be tested
at every test point ( Vitamin A* mandatory)
✓ All vitamins shall at least be tested at T0, T12,
T18*, T24 months and yearly (when
applicable).
✓ All minerals shall at least be tested at T0, T12,
T24 months and yearly (when applicable).
* MSF & UNICEF additional requirement
INTERAGENCY
REQUIREMENTS FOR STABILITY STUDY
Stability Testing Parameters (1/2)
Minimum testing requirements
❑ Microbial testing:
at the beginning and the end of the study
(every 6 months Preferred*)
❑ Stability of oils and fatty acids (peroxide
value, anisidine value, moisture content) ***
❑ Organoleptic stability: taste (rancidity,
acidity/bitterness, sweetness/savoury, etc),
odour, product consistency and behaviour
(absence of phase separation…) ***
❑ Integrity of the packing materials (absence of
leakage & availability of seal opening
notch)***
❑ Integrity of markings- (printing ink must be
of food grade standards for the products
intended to come in contact with food e.g.
(...) Date DDMMYYY Expiry Date DDMMYYY Stability Start DDMMYYYY
Batch /Lot Number Batch Size ( Kg and /M. ton) e.g. 500kg /MTON Batch Size (No. of Primary pack units)
Storage Conditions Relative Humidity e.g. 65 % or 75 % ± 5%e.g. 300C or 400C ±20C
Product Mfg site ( Name & address)
Result Discussion:
Conclusion & Storage Requirements (Based on results)
Stability Data Trend for Nutrition Products
Results from RUTF tender 2019
RUTF Vitamin A levels during stability testing- RUTF tender 2019 Suppliers- Monthly Interval Trend
Ref: Data on file- Stability reports- RUTF Tender 2019 9 suppliers were considered based on their completeness and reporting of stability data for minimum 18 - 24 months
RUTF- Vitamin A Levels during Pre - Delivery Inspection (PDI)-2018 Fresh stocks inspected before dispatch
Ref: Data on File- UNICFE PDI 2018
❑ Testing of Vitamin A levels in Premix,
➢ on goods receipt
➢ if stored more than a month
➢ before using in manufacturing process
❑ Testing of Vitamin A levels in RUTF
➢ After Batch release/ post production
o Aim for maximum specified limit
levels. e.g. RUTF – 1.1 mg /100
grams (limit 0.8-1.1 grams)
❑ Process validation of commercial batches
❑ Storage of Premix and Finished product at
recommended storage conditions
INTERAGENCY
REQUIREMENTS FOR STABILITY STUDY
Harnessing Vitamin A levels
Possible key interventions to
maintain Vitamin A levels
Language:English
Score: 1066799.5
-
https://www.unicef.org/supply/...ability-Study-Requirements.pdf
Data Source: un
While deaths attributed to vitamin A deficiency have been almost eliminated in most parts of the world, deficiency remains prevalent in South Asia and sub Saharan Africa according to a 2015 Lancet report.
(...) Regular clinical screenings for children are important to monitor their health and development and to look out for evidence of health problems like vitamin A deficiency. For Betânio Miguel, Director of the Moamba Health Centre, vitamin A deficiency is here in Mozambique, but it is difficult to identify or to measure the problem. (...) UNICEF/MOZA2020-00040/James Aldworth
A local APE (community health worker) stands in the doorway of a building that acts as the community health centre and post office in Sabie.
WHO recommends vitamin A supplementation, with a dose of 100,000 IU retinol in infants aged 6–11 months and 200,000 IU retinol at least twice a year in young children aged 12–59 months living in settings where vitamin A deficiency is a public health problem.
Language:English
Score: 1064221.7
-
https://www.unicef.org/mozambi...ved-child-nutrition-mozambique
Data Source: un
Vitamin A, Iron and Iodine help the body to function and grow properly.
(...) In areas where vitamin A deficiency is common, high-dose vitamin A supplements can also be given every four to six months to children aged 6 months to 5 years.
Until infants are 6 months old, breastmilk is the main source of vitamin A, provided the mother has enough vitamin A from her diet or supplements.
Language:English
Score: 1064184.9
-
https://www.unicef.org/uganda/...children-adolescents-and-women
Data Source: un