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  Dadu2x2

Dadu2x2 Vitamin D Vitamin E Vitamin K KALIUM FOLAT NATRIUM Kalsium Magnesium FOSFOR SENG BESI IODIUM Vitamin B1 Vitamin B2 Vitamin B3 Vitamin B5 Vitamin B6 Vitamin B12

Score: 1082732.9 - https://www.unicef.org/indonesia/id/media/8816/file

  0 Vitamin A Suppleme

0 Vitamin A Supplementation: Market and Supply Update UNICEF Supply Division June 2018 1 Vitamin A Supplementation Market and Supply Update – June 2018 1. (...) UNICEF procures vitamin A mostly as retinol, which is the animal form of vitamin A, with a minimum shelf-life of 24 months. (...) The trend in WAP reflects the impact of vitamin A API on the world market price, as most vitamin A API is destined for other uses in human and animal nutrition.

Score: 1079622.4 - https://www.unicef.org/supply/...n-market-and-supply-update.pdf

  Over 140 million children at greater risk of illness as they miss life-saving vitamin A supplements

Search Close Search UNICEF Fulltext search Max Press release Over 140 million children at greater risk of illness as they miss life-saving vitamin A supplements UNICEF urges immediate action as vitamin A coverage declines alarmingly, most starkly in West and Central Africa 02 May 2018 UNICEF/UN048391/Pirozzi A girl receives a dose of vitamin A at a basic health centre in Khan Pur Baga Sher Village, in Muzaffargarh District in Punjab Province. (...) But in 26 countries with the highest rates of child mortality – where vitamin A supplementation programmes are needed most – 62 million children missed vitamin A supplements in 2016, triple the number missed in 2015.    (...) At the same time, the report notes that until children have access to nutritious and safe diets that protect them from vitamin A deficiency, vitamin A supplementation programmes remain essential in many countries.  

Score: 1072818.7 - https://www.unicef.org/turkey/en/node/2531

  WHO | Nutrients

عربي 中文 English Français Русский Español Home Health Topics All topics » A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Resources » Fact sheets Facts in pictures Multimedia Publications Questions & answers Tools and toolkits Popular » Coronavirus disease (COVID-19) Ebola virus disease Air pollution Hepatitis Top 10 causes of death World Health Assembly » Countries All countries » A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Regions » Africa Americas South-East Asia Europe Eastern Mediterranean Western Pacific WHO in countries » Statistics Cooperation strategies Democratic Republic of the Congo »   Newsroom All news » News releases Statements Campaigns Commentaries Events Feature stories Speeches Spotlights Newsletters Photo library Media distribution list Headlines » Timeline: WHO's COVID-19 response »   Emergencies Focus on » COVID-19 pandemic Ebola virus disease outbreak DRC 2021 Syria crisis Crisis in Northern Ethiopia Afghanistan Crisis Latest » Disease Outbreak News Travel advice Situation reports Weekly Epidemiological Record WHO in emergencies » Surveillance Research Funding Partners Operations Independent Oversight and Advisory Committee Coronavirus disease outbreak (COVID-19) » WHO © Credits Data Data at WHO » Global Health Estimates Health SDGs Mortality Triple billion targets Data collections Dashboards » COVID-19 Dashboard Triple Billion Dashboard Health Equity monitor Mortality Highlights » GHO SCORE Insights and visualizations Data collection tools Reports World Health Statistics 2021 » WHO © Credits About WHO About WHO » People Teams Structure Partnerships Collaborating Centres Networks, committees and advisory groups Transformation Contact us » Governance » World Health Assembly Executive Board Election of Director-General Governing Bodies website Our Work » General Programme of Work WHO Academy Activities Initiatives Better health for everyone » WHO © Credits Skip to main content Access Home Alt+0 Navigation Alt+1 Content Alt+2 e-Library of Evidence for Nutrition Actions (eLENA) Menu eLENA A-Z list of interventions Health conditions Life course Nutrients Intervention type Interventions by category Global targets About eLENA How to use eLENA Nutrients Fruit and vegetables are excellent sources of vitamins and minerals WHO/Lori Sloate Several nutrients – including water – are essential for growth, reproduction and good health. Macronutrients are consumed in relatively large quantities and include proteins, carbohydrates, and fats and fatty acids. Micronutrients – vitamins and minerals – are consumed in relatively smaller quantities, but are essential to body processes. Carbohydrates Fibre Increasing fruit and vegetable consumption to reduce the risk of noncommunicable diseases Sugars Reducing consumption of sugar-sweetened beverages to reduce the risk of childhood overweight and obesity Reducing consumption of sugar-sweetened beverages to reduce the risk of unhealthy weight gain in adults Reducing free sugars intake in adults to reduce the risk of noncommunicable diseases Reducing free sugars intake in children to reduce the risk of noncommunicable diseases Fats and fatty acids Long chain polyunsaturated fatty acid supplementation during pregnancy Protein Balanced energy and protein supplementation during pregnancy Vitamins and minerals Calcium Calcium supplementation during pregnancy to reduce the risk of pre-eclampsia Folate Daily iron and folic acid supplementation during pregnancy Daily iron and folic acid supplementation during pregnancy in malaria-endemic areas Intermittent iron and folic acid supplementation during pregnancy Intermittent iron and folic acid supplementation during pregnancy in malaria-endemic areas Intermittent iron and folic acid supplementation in adult women and adolescent girls Intermittent iron and folic acid supplementation in adult women and adolescent girls in malaria-endemic areas Iron supplementation with or without folic acid to reduce the risk of postpartum anaemia Iron supplementation with or without folic acid to reduce the risk of postpartum anaemia in malaria-endemic areas Periconceptional folic acid supplementation to prevent neural tube defects Iodine Iodine supplementation in pregnant and lactating women Iodization of salt for the prevention and control of iodine deficiency disorders Iron Daily iron and folic acid supplementation during pregnancy Daily iron and folic acid supplementation during pregnancy in malaria-endemic areas Daily iron supplementation in adult women and adolescent girls Daily iron supplementation in children 24–59 months of age Daily iron supplementation in children 24–59 months of age in malaria-endemic areas Daily iron supplementation in children 6-23 months of age Daily iron supplementation in children 6-23 months of age in malaria-endemic areas Daily iron supplementation in children and adolescents 5–12 years of age Daily iron supplementation in children and adolescents 5–12 years of age in malaria-endemic areas Intermittent iron and folic acid supplementation during pregnancy Intermittent iron and folic acid supplementation during pregnancy in malaria-endemic areas Intermittent iron and folic acid supplementation in adult women and adolescent girls Intermittent iron and folic acid supplementation in adult women and adolescent girls in malaria-endemic areas Intermittent iron supplementation in preschool and school-age children Intermittent iron supplementation in preschool and school-age children in malaria-endemic areas Iron supplementation with or without folic acid to reduce the risk of postpartum anaemia Iron supplementation with or without folic acid to reduce the risk of postpartum anaemia in malaria-endemic areas Potassium Increasing potassium intake to control blood pressure in children Increasing potassium intake to reduce blood pressure and risk of cardiovascular diseases in adults Sodium Iodization of salt for the prevention and control of iodine deficiency disorders Reducing sodium intake to control blood pressure in children Reducing sodium intake to reduce blood pressure and risk of cardiovascular diseases in adults Vitamin A Vitamin A fortification of staple foods Vitamin A supplementation during pregnancy Vitamin A supplementation in children 6–59 months of age with severe acute malnutrition Vitamin A supplementation in children with respiratory infections Vitamin A supplementation in HIV-infected adults Vitamin A supplementation in HIV-infected infants and children 6–59 months of age Vitamin A supplementation in HIV-infected women during pregnancy Vitamin A supplementation in infants 1–5 months of age Vitamin A supplementation in infants and children 6–59 months of age Vitamin A supplementation in neonates Vitamin A supplementation in postpartum women Vitamin B6 Vitamin B6 supplementation during pregnancy Vitamin C Vitamin E and C supplementation during pregnancy Vitamin D Vitamin D supplementation and respiratory infections in children Vitamin D supplementation during pregnancy Vitamin D supplementation in infants Vitamin E Vitamin E and C supplementation during pregnancy Vitamin E supplementation for the prevention of morbidity and mortality in preterm infants Zinc Zinc supplementation and growth in children Zinc supplementation during pregnancy Zinc supplementation in children with respiratory infections Zinc supplementation in the management of diarrhoea Micronutrients Biofortification of staple crops Fortification of maize flour and corn meal Fortification of rice Fortification of wheat flour Micronutrient intake in children with severe acute malnutrition Micronutrient supplementation in HIV-infected women during pregnancy Micronutrient supplementation in individuals with active tuberculosis Micronutrient supplementation in low-birth-weight and very-low-birth-weight infants Multiple micronutrient powders for point-of-use fortification of foods consumed by children 2-12 years of age Multiple micronutrient powders for point-of-use fortification of foods consumed by children 6–23 months of age Multiple micronutrient powders for point-of-use fortification of foods consumed by pregnant women Multiple micronutrient supplementation during pregnancy Water Water, sanitation and hygiene interventions to prevent diarrhoea Multiple nutrients Balanced energy and protein supplementation during pregnancy Increasing fruit and vegetable consumption to reduce the risk of noncommunicable diseases Macronutrient supplementation in people living with HIV/AIDS Supplemental nutrition with dietary advice for older people affected by undernutrition Supplementary feeding in community settings for promoting child growth Supplementary foods for the management of moderate acute malnutrition in children aged 6 - 59 months Therapeutic feeding of children 6–59 months of age with severe acute malnutrition and acute or persistent diarrhoea Transition feeding of children 6–59 months of age with severe acute malnutrition Contact us eLENA team Department of Nutrition for Health and Development (NHD) World Health Organization 20 Avenue Appia CH-1211 Geneva 27 Switzerland E-mail: [email protected] WHO Department of Nutrition for Health and Development You are here: e-Library of Evidence for Nutrition Actions (eLENA) Nutrients Regions Africa Americas Eastern Mediterranean Europe South-East Asia Western Pacific About us Careers Library Procurement Publications Frequently asked questions Contact us Subscribe to our newsletters Privacy Legal Notice © 2022 WHO

Score: 1072495.7 - https://www.who.int/elena/nutrient/en/

  List of Validated Su

S0000225 A multiple micronutrient powder (MNP) supplement containing 15 essential vitamins and minerals in the base of a carrier,with customised labeling. (...) Supplement containing 15 essential vitamins and minerals in the base of a carrier. Each sachet weighs 1gram, supplied in boxes or pouches of 30 sachets. (...) Supplement containing 15 essential vitamins and minerals in the base of a carrier. Each sachet weighs 1gram, supplied in boxes or pouches of 30 sachets.

Score: 1070227.9 - https://www.unicef.org/supply/...0suppliers%20-%20nutrition.pdf

  WHO | Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infecti

Main results 4.1 Included studies Five randomized controlled trials, enrolling 7528 HIV-infected women, were included in this review Four studies were placebo-controlled, while one study compared vitamin A supplementation to standard care Four trials supplemented women in the antenatal period; two of these trials also supplemented women randomized to vitamin A treatment with high dose vitamin A (200,000 IU) at delivery, and in another study all women received 100,000 IU at six weeks’ postpartum, as per standard care in the region. Oral daily doses of vitamin A ranged from 3000 to 10,000 IU, and women were additionally supplemented with beta-carotene from 0 to 30 mg/day One trial was conducted in the postpartum period only, supplementing women with a single high dose of vitamin A (400,000 IU) or placebo, and also supplemented infants with a single high dose of vitamin A (50,000 IU) or placebo in a 2 x 2 factorial design Co-interventions included iron, folic acid and multivitamins; however, the use of antiretroviral agents was not well reported 4.2 Study settings Malawi, South Africa, the United Republic of Tanzania, and Zimbabwe (2 trials) Vitamin A deficiency in pregnant women was a moderate to severe public health problem in all included countries, as estimated in the WHO Global Database on Vitamin A Deficiency (2009) 4.3 Study settings How the data were analysed Vitamin A supplementation of HIV-infected women during pregnancy or the postpartum period was compared to placebo control or standard care. (...) Subgroup analyses were conducted by timing of maternal vitamin A supplementation, i.e., in the antenatal or postpartum period.

Score: 1069658.8 - https://www.who.int/elena/titl...ies/vitaminA-pregnancy-hiv/en/

  Vitamin and Mineral Nutrition Information System (VMNIS)

The objectives of the VMNIS are to: Systematically retrieve and summarize data on vitamin and mineral status of populations. Provide Member States with up-to-date national, regional, and global assessments of the magnitude of vitamin and mineral deficiencies. (...) Download Read More 30 May 2011 Serum retinol concentrations for determining the prevalence of vitamin A deficiency in populations This document aims to provide users of the Vitamin and Mineral Nutrition Information System (VMNIS) with information about the use of serum retinol for... (...) Download Read More 11 May 2009 Global prevalence of vitamin A deficiency in populations at risk 1995-2005 : WHO global database on vitamin...

Score: 1068633.6 - https://www.who.int/teams/nutr...l-nutrition-information-system

  PowerPoint Presentation

Also, when there is a, ❑ change of production site ❑ significant change in production equipment or process (e.g. heat treatment) ❑ modification of an existing product ❑ change in primary packaging material ❑ change of formulation or major ingredient, such as, but not limited to: i. raw material ii. vitamins & minerals premix iii. emulsifier ❑ change in supplier-only for vitamins & minerals premix and Vitamin A* * MSF & UNICEF additional requirement INTERAGENCY REQUIREMENTS FOR STABILITY STUDY When Stability Study is needed (2/2) ❑ Real time (long term) stability study should be conducted : ➢ at 30°C±2°C with 65% RH (if applicable) for the duration of the shelf life, and ➢ at 40°C±2°C with 75% RH (if applicable) for the duration of the shelf life ❑ Testing period and time points: ➢ minimum testing frequency : T0, T3, T6, T12, T18 and T24 months and then yearly for both temperatures ❑ Stability should be conducted on, at least 1 representative batch (prefer 2 batches*) * UNICEF additional requirement INTERAGENCY REQUIREMENTS FOR STABILITY STUDY Type of stability studies required For Real Time Stability Study Minimum protocol requirements ❑ Accelerated stability study should be conducted : ➢ at 40°C±2°C with 75% RH (if applicable) ❑ Testing period and time points: ➢ minimum testing frequency : T0, T1, T2, T3 and T6 months ❑ Stability should be conducted on, at least 1 representative batch (prefer 2 batches*) * UNICEF additional requirement INTERAGENCY REQUIREMENTS FOR STABILITY STUDY Type of stability studies required For Accelerated Stability Study Minimum protocol requirements ❑ Stability batch should be, ➢ Commercial batch size (Preferred*) ➢ Process validated (Preferred*) ➢ Produced with the same vitamins & minerals premix and / or Vitamin A, source to be used in the commercial finished product ➢ Manufactured ONLY by the product manufacturer ➢ Pilot scale batch MAY be accepted, subject to prior approval only ➢ For Pilot scale batch-method of manufacture and procedure MUST simulate the final process to be used for production batches * UNICEF additional requirement INTERAGENCY REQUIREMENTS FOR STABILITY STUDY Stability Batch Size Minimum requirements ❑ Monitoring of relative humidity is not mandatory ❑ If the shelf life study is performed in an incubator ✓ Relative humidity must be set at 65% and 75%. ✓ RH (Relative Humidity) can vary ±5%* ❑ Temperature and relative humidity (if applicable) must be regularly controlled and recorded. ❑ The record of calibration of incubator(s) shall be available upon request. * UNICEF additional requirement INTERAGENCY REQUIREMENTS FOR STABILITY STUDY Relative Humidity (RH) Minimum requirements ❑ All the tests shall be performed in ISO17025 accredited laboratories (Preferred) ❑ Stability studies must verify the following parameters ❑ Micronutrient stability: ✓ Minimum 1 water soluble vitamin (vitamin C mandatory) shall be tested at every test point ✓ Minimum 1 fat soluble vitamin shall be tested at every test point ( Vitamin A* mandatory) ✓ All vitamins shall at least be tested at T0, T12, T18*, T24 months and yearly (when applicable). ✓ All minerals shall at least be tested at T0, T12, T24 months and yearly (when applicable). * MSF & UNICEF additional requirement INTERAGENCY REQUIREMENTS FOR STABILITY STUDY Stability Testing Parameters (1/2) Minimum testing requirements ❑ Microbial testing: at the beginning and the end of the study (every 6 months Preferred*) ❑ Stability of oils and fatty acids (peroxide value, anisidine value, moisture content) *** ❑ Organoleptic stability: taste (rancidity, acidity/bitterness, sweetness/savoury, etc), odour, product consistency and behaviour (absence of phase separation…) *** ❑ Integrity of the packing materials (absence of leakage & availability of seal opening notch)*** ❑ Integrity of markings- (printing ink must be of food grade standards for the products intended to come in contact with food e.g. (...) Date DDMMYYY Expiry Date DDMMYYY Stability Start DDMMYYYY Batch /Lot Number Batch Size ( Kg and /M. ton) e.g. 500kg /MTON Batch Size (No. of Primary pack units) Storage Conditions Relative Humidity e.g. 65 % or 75 % ± 5%e.g. 300C or 400C ±20C Product Mfg site ( Name & address) Result Discussion: Conclusion & Storage Requirements (Based on results) Stability Data Trend for Nutrition Products Results from RUTF tender 2019 RUTF Vitamin A levels during stability testing- RUTF tender 2019 Suppliers- Monthly Interval Trend Ref: Data on file- Stability reports- RUTF Tender 2019 9 suppliers were considered based on their completeness and reporting of stability data for minimum 18 - 24 months RUTF- Vitamin A Levels during Pre - Delivery Inspection (PDI)-2018 Fresh stocks inspected before dispatch Ref: Data on File- UNICFE PDI 2018 ❑ Testing of Vitamin A levels in Premix, ➢ on goods receipt ➢ if stored more than a month ➢ before using in manufacturing process ❑ Testing of Vitamin A levels in RUTF ➢ After Batch release/ post production o Aim for maximum specified limit levels. e.g. RUTF – 1.1 mg /100 grams (limit 0.8-1.1 grams) ❑ Process validation of commercial batches ❑ Storage of Premix and Finished product at recommended storage conditions INTERAGENCY REQUIREMENTS FOR STABILITY STUDY Harnessing Vitamin A levels Possible key interventions to maintain Vitamin A levels

Score: 1066799.5 - https://www.unicef.org/supply/...ability-Study-Requirements.pdf

  Vitamin A supplementation supports improved child nutrition in Mozambique | UNICEF

While deaths attributed to vitamin A deficiency have been almost eliminated in most parts of the world, deficiency remains prevalent in South Asia and sub Saharan Africa according to a 2015 Lancet report.  (...) Regular clinical screenings for children are important to monitor their health and development and to look out for evidence of health problems like vitamin A deficiency. For Betânio Miguel, Director of the Moamba Health Centre, vitamin A deficiency is here in Mozambique, but it is difficult to identify or to measure the problem. (...) UNICEF/MOZA2020-00040/James Aldworth A local APE (community health worker) stands in the doorway of a building that acts as the community health centre and post office in Sabie. WHO recommends vitamin A supplementation, with a dose of 100,000 IU retinol in infants aged 6–11 months and 200,000 IU retinol at least twice a year in young children aged 12–59 months living in settings where vitamin A deficiency is a public health problem.

Score: 1064221.7 - https://www.unicef.org/mozambi...ved-child-nutrition-mozambique

  Key practice: Micronutrients for children, adolescents and women | UNICEF Uganda

Vitamin A, Iron and Iodine help the body to function and grow properly. (...) In areas where vitamin A deficiency is common, high-dose vitamin A supplements can also be given every four to six months to children aged 6 months to 5 years. Until infants are 6 months old, breastmilk is the main source of vitamin A, provided the mother has enough vitamin A from her diet or supplements.

Score: 1064184.9 - https://www.unicef.org/uganda/...children-adolescents-and-women